Results 101 to 110 of about 7,546,530 (304)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

The Visible Aspect of Things: Towards a Synchronic Reading of Donald Barthelme

open access: yesEuropean Journal of American Studies, 2018
This essay seeks to address a distinct lacuna in criticism regarding the American author Donald Barthelme, one comprised of two dimensions. First, there is a scarcity of analysis of fragments in works apart from Snow White.
Surya Bowyer
doaj   +1 more source

Designing Verbal Message And Visual Media Of Quick Chicken [PDF]

open access: yes, 2019
Quick Chicken currently exists on more than 8 islands, more than 17 provinces, more than 220 outlets. Compared to similar fried chicken outlets, Quick Chicken outlet designs are more attractive because they use the concept of selling in containers.
Dewi, N. R. (Nanda Ayu )   +1 more
core  

Image classification by visual bag-of-words refinement and reduction

open access: yes, 2015
This paper presents a new framework for visual bag-of-words (BOW) refinement and reduction to overcome the drawbacks associated with the visual BOW model which has been widely used for image classification.
Lu, Zhiwu, Wang, Liwei, Wen, Ji-Rong
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Topographica: building and analyzing map-level simulations from Python, C/C++, MATLAB, NEST, or NEURON components

open access: yesFrontiers in Neuroinformatics, 2009
Many neural regions are arranged into two-dimensional topographic maps, such as the retinotopic maps in mammalian visual cortex. Computational simulations have led to valuable insights about how cortical topography develops and functions, but further ...
James A Bednar
doaj   +1 more source

Functional representation of vision within the mind: A visual consciousness model based in 3D default space [PDF]

open access: yes, 2015
The human eyes and brain, which have finite boundaries, create a ‘‘virtual’’ space within our central nervous system that interprets and perceives a space that appears boundless and infinite.
Barnes, Vernon A.   +2 more
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Influence of practice on visual reaction time

open access: yesJournal of Mahatma Gandhi Institute of Medical Sciences, 2014
Background: The present study was aimed to see the effect of practice on visual information processing speed. Reaction time is one of the important physiological parameters, which gives information how fast and quickly person responses.
Tejas P Ghuntla   +3 more
doaj   +1 more source

Visual Adaptation [PDF]

open access: yesAnnual Review of Vision Science, 2015
Sensory systems continuously mold themselves to the widely varying contexts in which they must operate. Studies of these adaptations have played a long and central role in vision science, partly because the specific adaptations remain a powerful tool for dissecting vision by exposing the mechanisms that are adapting. That is, “if it adapts, it's there.”
openaire   +2 more sources

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