Results 81 to 90 of about 2,024,771 (269)

Acessibilidade e inclusão de uma aluna com deficiência visual na escola e na educação física

open access: yesRevista Brasileira de Ciências do Esporte, 2011
O presente estudo tem como problema de investigação compreender como a escola e as aulas de Educação Física apresentam condições de acessibilidade e de inclusão para uma aluna com deficiência visual na escola comum.
Jane Márcia Mazzarino   +2 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

The Visible Aspect of Things: Towards a Synchronic Reading of Donald Barthelme

open access: yesEuropean Journal of American Studies, 2018
This essay seeks to address a distinct lacuna in criticism regarding the American author Donald Barthelme, one comprised of two dimensions. First, there is a scarcity of analysis of fragments in works apart from Snow White.
Surya Bowyer
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Topographica: building and analyzing map-level simulations from Python, C/C++, MATLAB, NEST, or NEURON components

open access: yesFrontiers in Neuroinformatics, 2009
Many neural regions are arranged into two-dimensional topographic maps, such as the retinotopic maps in mammalian visual cortex. Computational simulations have led to valuable insights about how cortical topography develops and functions, but further ...
James A Bednar
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

open access: yesFEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Influence of practice on visual reaction time

open access: yesJournal of Mahatma Gandhi Institute of Medical Sciences, 2014
Background: The present study was aimed to see the effect of practice on visual information processing speed. Reaction time is one of the important physiological parameters, which gives information how fast and quickly person responses.
Tejas P Ghuntla   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

A visual environment for visual languages

open access: yesScience of Computer Programming, 2002
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

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