Results 31 to 40 of about 736 (237)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

JWST Observations of the Enigmatic Y-Dwarf WISE 1828+2650. I. Limits to a Binary Companion

The Astrophysical Journal, 2023
The Y-dwarf WISE 1828+2650 is one of the coldest known brown dwarfs with an effective temperature of ∼300 K. Located at a distance of just 10 pc, previous model-based estimates suggest WISE1828+2650 has a mass of ∼5–10 M _J , making it a valuable ...
Matthew De Furio, Ben Lew, Charles Beichman, Thomas Roellig, Geoffrey Bryden, David Ciardi, Michael Meyer, Marcia Rieke, Alexandra Greenbaum, Jarron Leisenring, Jorge Llop-Sayson, Marie Ygouf, Loic Albert, Martha Boyer, Daniel Eisenstein, Klaus Hodapp, Scott Horner, Doug Johnstone, Doug Kelly, Karl Misselt, George Rieke, John Stansberry, Erick Young   +22 more
doaj   +1 more source

Binary star astrometry with milli and sub-milli arcsecond precision [PDF]

Serbian Astronomical Journal, 2014
The past several decades have seen accelerating progress in improving binary stars fundamental parameters determinations, as new observational techniques have produced visual orbits of many spectroscopic binaries with a milli arcsecond precision.
Jankov S., Cvetković Z., Pavlović R.
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Five New Sirius-like White Dwarf–Main-sequence Star Systems with MagAO-X

The Astronomical Journal
Most known white dwarfs in multiple systems with main-sequence stars have been discovered with M-type companions, because the white dwarf causes detectable UV excess and bluer colors than expected from a single M star.
Logan A. Pearce, Jared R. Males, Sebastiaan Y. Haffert, Laird M. Close, Joseph D. Long, Eden A. McEwen, Joshua Liberman, Maggie Y. Kautz, Jay K. Kueny, Alycia J. Weinberger, Jialin Li, Elena Tonucci, Katie Twitchell, Avalon L. McLeod, Warren B. Foster, Olivier Guyon, Alexander D. Hedglen, Kyle Van Gorkom, Jennifer Lumbres, Lauren Schatz, Victor Gasho, Katie M. Morzinski, Phil M. Hinz   +22 more
doaj   +1 more source

The Census of Exoplanets in Visual Binaries: Population Trends from a Volume-Limited Gaia DR2 and Literature Search

Frontiers in Astronomy and Space Sciences, 2021
We present results from an extensive search in the literature and Gaia DR2 for visual co-moving binary companions to stars hosting exoplanets and brown dwarfs within 200 pc.
Clémence Fontanive, Daniella Bardalez Gagliuffi   +1 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Modelling and observations of molecules in discs around young stars [PDF]

, 2013
This thesis contains a study of molecules within circumstellar discs around young stars. Firstly, the chemistry of a disc around a young, Class 0 protostar is modelled.
Ilee, John David
core  

Performance of the SOAR Speckle Instrument

The Astronomical Journal
The High Resolution Camera (HRCam) speckle imager at the 4.1 m Southern Astrophysical Research telescope is a highly productive instrument that has accumulated about 40K observations to date.
Andrei Tokovinin
doaj   +1 more source