Results 111 to 120 of about 2,981,639 (311)

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Local and global limits on visual processing in schizophrenia. [PDF]

, 2015
Schizophrenia has been linked to impaired performance on a range of visual processing tasks (e.g. detection of coherent motion and contour detection).
Steven C. Dakin, Bobin, Tracy; id_orcid, Anderson, EJ, Patricia Carlin, Carlin Patricia, Elaine J Anderson, Steven C. Dakin (400934), Marc S Tibber, Tibber, Marc S., Anderson, Elaine J., Shergill, SS, Tracy Bobin, Carlin, P, Dakin, Steven C., Tibber Marc S., Dakin, SC, Tracy Bobin (400932), Elaine J. Anderson, Sukhwinder S Shergill, Steven C Dakin, Marc S. Tibber, Tibber, MS, Elaine J. Anderson (374473), Shergill Sukhwinder S., Bobin Tracy, Marc S. Tibber (374472), Sukhwinder S. Shergill (320100), Anderson Elaine J., Bobin, T, Sukhwinder S. Shergill, Dakin Steven C., Patricia Carlin (400933), Carlin, Patricia, Shergill, Sukhwinder S.   +33 more
core   +2 more sources

Online platform vs. doctors: a comparative exploration of congenital cataract patient education from virtual to reality

Frontiers in Artificial Intelligence
ObjectiveThis study aimed to assess the quality and readability of patient education on congenital cataracts provided by Google, ChatGPT, and clinical doctors. Given the rarity of congenital cataracts and the need for accessible, accurate information for
Xuanqiao Lin, Xuanqiao Lin, Xuanqiao Lin, Xuanqiao Lin, Lifang Bai, Lifang Bai, Lifang Bai, Lifang Bai, Xiaohuan Zhao, Xiaohuan Zhao, Xiaohuan Zhao, Xiaohuan Zhao, Lei Cai, Lei Cai, Lei Cai, Lei Cai, Jin Yang, Jin Yang, Jin Yang, Jin Yang   +19 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Overexpression of Optic Atrophy Type 1 Protects Retinal Ganglion Cells and Upregulates Parkin Expression in Experimental Glaucoma

Frontiers in Molecular Neuroscience, 2018
Glaucoma is a neurodegenerative disease that features progressive loss of retinal ganglion cells (RGCs). Increasing evidences have revealed that impaired mitochondrial dynamics occurs early in neurodegenerative diseases.
Xinxin Hu, Xinxin Hu, Xinxin Hu, Xinxin Hu, Yi Dai, Yi Dai, Yi Dai, Yi Dai, Rong Zhang, Rong Zhang, Rong Zhang, Kunte Shang, Kunte Shang, Kunte Shang, Kunte Shang, Xinghuai Sun, Xinghuai Sun, Xinghuai Sun, Xinghuai Sun, Xinghuai Sun   +19 more
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Prevalence and factors associated with childhood visual impairment in Ethiopia

, 2017
Lidiya Bezabih,1 Tilaye Workneh Abebe,1 Robera Olana Fite2 1Department of Public Health, College of Health Sciences, Adama General Hospital and Medical College, Adama, 2Department of Nursing, College of Medicine and Health Sciences, Wolaita Sodo ...
Abebe TW, Fite RO, Bezabih L
core  

Design and evaluation of FEBS Education and Training Academy module – Integrating generative artificial intelligence into life‐science education

FEBS Open Bio, EarlyView.
Life‐science educators from 14 countries redesigned their own course materials with generative AI in a three‐session, pedagogy‐first FEBS Education and Training Academy workshop built on PICRAT. Among 12 matched respondents, four more reported high confidence in each of five practical domains, and 10 of 13 reported implementing at least one idea ...
Zvonimir Mlinarić, Ali Burak Özkaya
wiley   +1 more source