Results 111 to 120 of about 406,069 (249)

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Online platform vs. doctors: a comparative exploration of congenital cataract patient education from virtual to reality

Frontiers in Artificial Intelligence
ObjectiveThis study aimed to assess the quality and readability of patient education on congenital cataracts provided by Google, ChatGPT, and clinical doctors. Given the rarity of congenital cataracts and the need for accessible, accurate information for
Xuanqiao Lin, Xuanqiao Lin, Xuanqiao Lin, Xuanqiao Lin, Lifang Bai, Lifang Bai, Lifang Bai, Lifang Bai, Xiaohuan Zhao, Xiaohuan Zhao, Xiaohuan Zhao, Xiaohuan Zhao, Lei Cai, Lei Cai, Lei Cai, Lei Cai, Jin Yang, Jin Yang, Jin Yang, Jin Yang   +19 more
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Overexpression of Optic Atrophy Type 1 Protects Retinal Ganglion Cells and Upregulates Parkin Expression in Experimental Glaucoma

Frontiers in Molecular Neuroscience, 2018
Glaucoma is a neurodegenerative disease that features progressive loss of retinal ganglion cells (RGCs). Increasing evidences have revealed that impaired mitochondrial dynamics occurs early in neurodegenerative diseases.
Xinxin Hu, Xinxin Hu, Xinxin Hu, Xinxin Hu, Yi Dai, Yi Dai, Yi Dai, Yi Dai, Rong Zhang, Rong Zhang, Rong Zhang, Kunte Shang, Kunte Shang, Kunte Shang, Kunte Shang, Xinghuai Sun, Xinghuai Sun, Xinghuai Sun, Xinghuai Sun, Xinghuai Sun   +19 more
doaj   +1 more source

Visual impairment secondary to congenital glaucoma in children: visual responses, optical correction and use of low vision AIDS [PDF]

, 2009
INTRODUCTION: Congenital glaucoma is frequently associated with visual impairment due to optic nerve damage, corneal opacities, cataracts and amblyopia.
BETINJANE, Alberto Jorge, HADDAD, Maria Aparecida Onuki, KARA-JOSÉ, Newton, OLTROGGE, Ernst Werner, SAMPAIO, Marcos Wilson   +4 more
core   +5 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Seeing and doing: Feasibility study towards valuing visual impairment using simulation spectacles [PDF]

, 2007
Elicitation of utilities from those who do not have the health condition of interest generally uses verbal description of health states. This paper reports on the results of a small-scale investigation on the feasibility of an alternative approach, where
Aballéa, S., Tsuchiya, A.
core  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source