Results 101 to 110 of about 406,069 (249)

Ivermectin for onchocercal eye disease (river blindness).

, 2012
BACKGROUND: It is believed that ivermectin (a microfilaricide) could prevent blindness due to onchocerciasis. However, when given to everyone in communities where onchocerciasis is common, the effects of ivermectin on lesions affecting the eye are ...
Ejere, Henry OD, Evans, Jennifer R, Schwartz, Ellen, Wormald, Richard   +3 more
core   +1 more source

Quality of life and visual function in Nigeria: findings from the National Survey of Blindness and Visual Impairment [PDF]

, 2011
Aims To assess associations of visual function (VF) and quality of life (QOL) by visual acuity (VA), causes of blindness and types of cataract procedures in Nigeria. Methods Multi-stage stratified cluster random sampling was used to identify a nationally
Abubakar, T, Bankole, OO, Ezelum, CC, Gilbert, CE, Gudlavalleti, MVS, Mahdi, AM, Nigeria Natl, B, Shah, SP, Sivasubramaniam, S, Tran, HM, Visual, I   +10 more
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Submovements During Reaching Movements after Stroke [PDF]

, 2014
Neurological deficits after cerebrovascular accidents very frequently disrupt the kinematics of voluntary movements with the consequent impact in daily life activities.
Ghez, Claude, Laczko, Jozsef, Piovesan, Davide, Scheidt, Robert A., Simo, Lucia S.   +4 more
core   +2 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

The Precise Diagnosis of Wolfram Syndrome Type 1 Based on Next-Generation Sequencing

Frontiers in Genetics, 2019
Purpose: To explore a method for the early, rapid and accurate diagnosis of Wolfram syndrome 1 (WS1) and further enrich the spectrum of WFS1 mutations in the Chinese population.Methods: We analyzed 279 patients with unexplained optic atrophy using next ...
Dan-Dan Wang, Dan-Dan Wang, Dan-Dan Wang, Fang-Yuan Hu, Fang-Yuan Hu, Fang-Yuan Hu, Feng-Juan Gao, Feng-Juan Gao, Feng-Juan Gao, Sheng-Hai Zhang, Sheng-Hai Zhang, Sheng-Hai Zhang, Ping Xu, Ping Xu, Ping Xu, Guo-Hong Tian, Guo-Hong Tian, Guo-Hong Tian, Ji-Hong Wu, Ji-Hong Wu, Ji-Hong Wu   +20 more
doaj   +1 more source

Magnitude, temporal trends, and projections of the global prevalence of blindness and distance and near vision impairment: a systematic review and meta-analysis [PDF]

, 2017
Background: Global and regional prevalence estimates for blindness and vision impairment are important for the development of public health policies. We aimed to provide global estimates, trends, and projections of global blindness and vision impairment.
Aditi Das, Aditi Das, MD, Alain Bron, Alan Morse, Alan Robin, Alex Silvester, Alex Silvester, MD, Anu Mathew, April Ingram, Aries Arditi, Banu Bozkurt, Beatriz Munoz, Billy Hammond, Charlotte Joslin, David Friedman, David Musch, Donald Budenz, Dwight Stambolian, Feng Cai, Fernando Yaacov Pena, Flavio Hirai, George Lambrou, Gianni Virgili, Gretchen A Stevens, DSc, Gretchen Stevens, Gus Gazzard, Hans LIMBURG, Hans Limburg, PhD, Harry Quigley, Hua Gao, Hugh R Taylor, MD, Hugh Taylor, Iva Dekaris, Jaewan Choi, Jaime Tejedor, James Hejtmancik, James Tielsch, Jan van Meurs, Janet Leasher, Janet Leasher, OD, Janet Serle, Jennifer Lim, Jenny Deva, Jill Keeffe, Jill Keeffe, PhD, Jimmy Volmink, Jinan Saaddine, Joao Furtado, John H Kempen, MD, John Huang, John Kempen, Jonathan Javitt, Jost B Jonas, MD, Jost Jonas, Juan Carlos Silva, Judy Kim, Kaweh Mansouri, Kevin Frick, Konrad Pesudovs, Konrad Pesudovs, PhD, Kovin Naidoo, Kovin Naidoo, PhD, Lalit Dandona, Laura Dreer, Leon Ellwein, Luca Rossetti, Marcela Frazier, MARIA PALAIOU, Maria V Cicinelli, MD, Maria Vittoria Cicinelli, Mary Elizabeth Hartnett, Maurizio Battaglia Parodi, Miltiadis Tsilimbaris, Minguang He, Moncef Khairallah, Monte Del Monte, Murugesan Raju, MYA SANDAR, Nathan Congdon, Nina Tahhan, PhD, Ning-Li Wang, Pamela Sieving, Paolo Lanzetta, Peter Ackland, Peter Wiedemann, Pradeep Ramulu, Prof Rupert R A Bourne, MD, Rajesh Shetty, Rakhi Dandona, Reza Dana, Richard Wormald, Rita S Sitorus, Robert Casson, Rohit Khanna, Rohit Varma, Ronnie George, Rupert Bourne, Serge Resnikoff, Serge Resnikoff, MD, Seth R Flaxman, BA, Sheila West, Stephen Gichuhi, TASANEE BRAITHWAITE, Tasanee Braithwaite, MPH, Tien Wong, Tien Y Wong, PhD, Tueng Shen, Tunde Peto, Usha Chakravarthy, Van Charles Lansingh, Victor Gonzalez, Vinay Nangia, Ya Xing Wang, Yaniv Barkana, Yingfeng Zheng   +114 more
core   +10 more sources

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Instructional Design for Students with Visual Impairments in English Learning [PDF]

, 2011
Mastering English has become one important skill for students in higher education, especially in university level. As the impact, every university provides English program for students in the faculty or language center.
Aryanti, W. (Widya), Farani, R. (Rizki)
core  

What is the global burden of visual impairment? [PDF]

, 2006
Background A recent estimate by the World Health Organization (WHO) suggests that 161 million persons worldwide have visual impairment, including 37 million blind (best-corrected visual acuity less than 3/60 in the better eye) and 124 million with visual
Lalit Dandona, Rakhi Dandona
core   +2 more sources