Results 101 to 110 of about 4,362,153 (359)

Local and global limits on visual processing in schizophrenia. [PDF]

, 2015
Schizophrenia has been linked to impaired performance on a range of visual processing tasks (e.g. detection of coherent motion and contour detection).
Steven C. Dakin, Bobin, Tracy; id_orcid, Anderson, EJ, Patricia Carlin, Carlin Patricia, Elaine J Anderson, Steven C. Dakin (400934), Marc S Tibber, Tibber, Marc S., Anderson, Elaine J., Shergill, SS, Tracy Bobin, Carlin, P, Dakin, Steven C., Tibber Marc S., Dakin, SC, Tracy Bobin (400932), Elaine J. Anderson, Sukhwinder S Shergill, Steven C Dakin, Marc S. Tibber, Tibber, MS, Elaine J. Anderson (374473), Shergill Sukhwinder S., Bobin Tracy, Marc S. Tibber (374472), Sukhwinder S. Shergill (320100), Anderson Elaine J., Bobin, T, Sukhwinder S. Shergill, Dakin Steven C., Patricia Carlin (400933), Carlin, Patricia, Shergill, Sukhwinder S.   +33 more
core   +1 more source

Development of a machine learning model to predict low vision aid fitting for visually impaired patients

Frontiers in Medicine
BackgroundAt present, the fitting of low-vision aids (LVA) for patients globally necessitates the intervention of highly skilled ophthalmologists and certified rehabilitation specialists.
Bingfa Dai, Bingfa Dai, Pengpeng Pei, Zunqi Kan, Hai Lan, Wenwen Ye, Wenwen Ye, Yang Yu, Yang Yu, Xuelan Chen, Xuelan Chen, Yuyuan Yan, Yuyuan Yan, Ting Chen, Ting Chen, Jianqing Zheng, Jianqing Zheng, Lijuan Huang, Lijuan Huang, Jianmin Hu, Jianmin Hu   +20 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Are we blind to the injuries in the visually impaired? A review of the literature [PDF]

, 2002
Objectives: To review the literature on the risks and types of injuries associated with visual impairment, and to identify pertinent areas for future research.
Scuffham, Paul, Legood, R, Scuffham, P, Cryer, Colin, Cryer, C, Legood, R.   +5 more
core   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Spatial Localization in Visual Impairment

Investigative Opthalmology & Visual Science, 2006
To investigate self-reported difficulties experienced by visually impaired subjects in real-world tasks requiring judgment of space and distance and to determine whether laboratory measures of spatial localization predict self-reported difficulty with spatial tasks better than traditional measures of visual function, such as visual acuity and contrast ...
Subramanian, Ahalya, Dickinson, Christine; id_orcid 0000-0003-2638-800X   +1 more
openaire   +3 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Developments of the Assistive Tool and Database System for Orientation and Mobility of People with Visual Impairment and their Outreach Activity [PDF]

, 2017
We developed the database system that accumulates the analysis of causes in falling accidents at the station platform and the tactile map kit to support the Orientation and Mobility of people with visual impairment.
大倉, 元宏, 豊田, 航, TOYODA, Wataru, OHKURA, Motohiro   +3 more
core   +1 more source