Results 81 to 90 of about 2,981,639 (311)
Spatial Localization in Visual Impairment
Investigative Opthalmology & Visual Science, 2006 To investigate self-reported difficulties experienced by visually impaired subjects in real-world tasks requiring judgment of space and distance and to determine whether laboratory measures of spatial localization predict self-reported difficulty with spatial tasks better than traditional measures of visual function, such as visual acuity and contrast ...
Subramanian, Ahalya +1 more
openaire +3 more sources
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Effect of visual impairment on driving
, 1994 The aim of the study was to determine the effect on driving of restricting vision. This was undertaken by comparing the driving performance of young, normal subjects under conditions of simulated visual impairment with a baseline condition.
Wood, Joanne M. +3 more
core +1 more source
Are we blind to the injuries in the visually impaired? A review of the literature [PDF]
, 2002 Objectives: To review the literature on the risks and types of injuries associated with visual impairment, and to identify pertinent areas for future research.
Scuffham, Paul +6 more
core +1 more source
Glaucoma and visual impairment.
, 2021 Glaucoma and visual impairment.
Mengesha Assefa Ahunie (11273486) +1 more
core +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
A Behavioural and Electrophysiological exploration of the Working Memory impairment in Developmental Dyslexia [PDF]
, 2015 The current thesis provides a behavioural and electrophysiological exploration of Working Memory (WM) processing in developmental dyslexia. This thesis identifies a debate in the literature regarding the extent to which individuals with dyslexia have a ...
Ahmad, Jumana
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