Results 61 to 70 of about 2,981,639 (311)

MicroRNA-21-5p from induced pluripotent stem cells promotes neuroprotection of retinal ganglion cells in optic nerve crush model

BMC Ophthalmology
Introduction Retinal ganglion cells (RGCs) are susceptible to degenerative conditions such as glaucoma and traumatic optic neuropathies, which lead to vision loss.
Qing Xia, Wei Chen, Jiawei Xiong, Xiaofen Mo   +3 more
doaj   +1 more source

Replication of the Association Between Keratoconus and Polymorphisms in PNPLA2 and MAML2 in a Han Chinese Population

Frontiers in Genetics, 2020
Keratoconus (KC) is a complex ocular disease that is affected by both genetic and non-genetic triggers. A recent genome-wide association study (GWAS) identified a genome-wide significant locus for KC in the region of PNPLA2 (rs61876744), as well as a ...
Jing Zhang, Jing Zhang, Jing Zhang, Yue Li, Yue Li, Yue Li, Yiqin Dai, Yiqin Dai, Yiqin Dai, Jianjiang Xu, Jianjiang Xu, Jianjiang Xu   +11 more
doaj   +1 more source

Accessibility and Visually Impaired Users [PDF]

, 2006
Internet accessibility for the visually impaired community is still an open issue. Guidelines have been issued by the W3C consortium to help web designers to improve web site accessibility. However several studies show that a significant percentage of web page creators are still ignoring the proposed guidelines. Several tools are now available, general
António Fernandes, Jorge Pereira, José Creissac Campos   +2 more
openaire   +4 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Varying Clinical Phenotypes of Mitochondrial DNA T12811C Mutation: A Case Series Report

Frontiers in Medicine, 2022
The T12811C mitochondrial DNA (mtDNA) mutation has been reported in Leber hereditary optic neuropathy (LHON) previously, with vision loss as the main manifestation.
Qingdan Xu, Ping Sun, Chaoyi Feng, Qian Chen, Xinghuai Sun, Xinghuai Sun, Xinghuai Sun, Yuhong Chen, Yuhong Chen, Guohong Tian, Guohong Tian   +10 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Pre-treatment With Ranibizumab Aggravates PDT Injury and Alleviates Inflammatory Response in Choroid-Retinal Endothelial Cells

Frontiers in Cell and Developmental Biology, 2020
Polypoidal choroidal vasculopathy (PCV) is the predominant subtype of exudative age-related macular degeneration in Asians. Although photodynamic therapy (PDT) is widely used for PCV treatment, its long-term beneficial effects are unsatisfactory ...
Yang Liu, Yang Liu, Min Zhu, Min Zhu, Ruowen Gong, Ruowen Gong, Xin Wang, Xin Wang, Lei Li, Lei Li, Gezhi Xu, Gezhi Xu   +11 more
doaj   +1 more source

The profiles and clinical significance of extraocular muscle-expressed lncRNAs and mRNAs in oculomotor nerve palsy

Frontiers in Molecular Neuroscience, 2023
IntroductionOculomotor nerve palsy (ONP) arises from primary abnormalities in the central neural pathways that control the extraocular muscles (EOMs).
Lianqun Wu, Lianqun Wu, Lianqun Wu, Mingsu Shi, Mingsu Shi, Mingsu Shi, Yu Liang, Yu Liang, Yu Liang, Jiaqiu Huang, Jiaqiu Huang, Jiaqiu Huang, Weiyi Xia, Weiyi Xia, Weiyi Xia, Hewei Bian, Hewei Bian, Hewei Bian, Qiao Zhuo, Qiao Zhuo, Qiao Zhuo, Chen Zhao, Chen Zhao, Chen Zhao   +23 more
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Visual impairment in the hearing impaired students

Indian Journal of Ophthalmology, 2009
Ocular problems are more common in children with hearing problems than in normal children. Neglected visual impairment could aggravate educational and social disability.To detect and treat visual impairment, if any, in hearing-impaired children.Observational, clinical case series of hearing-impaired children in schools providing special education ...
Gogate Parikshit, Rishikeshi Nikhil, Mehata Reshma, Ranade Satish, Kharat Jitesh, Deshpande Madan   +5 more
openaire   +3 more sources