Results 51 to 60 of about 401,751 (264)

SHP-2-Induced Activation of c-Myc Is Involved in PDGF-B-Regulated Cell Proliferation and Angiogenesis in RMECs

Frontiers in Physiology, 2020
Background: Aberrant neovascularization resulting from inappropriate angiogenic signaling is closely related to many diseases, such as cancer, cardiovascular disease, and proliferative retinopathy.
Jun Ma, Jun Ma, Wenyi Tang, Ruiping Gu, Fangyuan Hu, Fangyuan Hu, Lei Zhang, Jihong Wu, Jihong Wu, Gezhi Xu, Gezhi Xu   +10 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Metabolic characterization of human aqueous humor in the cataract progression after pars plana vitrectomy

BMC Ophthalmology, 2018
Background While pars plana vitrectomy (PPV) has become the third most commonly performed surgery in the world, it can also induce multiple post complications easily.
Yinghong Ji, Xianfang Rong, Yi Lu
doaj   +1 more source

Heterogeneity of Axenfeld–Rieger Syndrome: Molecular and Clinical Findings in Chinese Patients

Frontiers in Genetics, 2021
Axenfeld–Rieger Syndrome (ARS) is a rare disease with a wide spectrum of ocular and systemic manifestations. The genetic spectrum of Chinese patients with ARS and genotype-phenotype correlations have yet to be described.
Youjia Zhang, Youjia Zhang, Xueli Chen, Li Wang, Xinghuai Sun, Xinghuai Sun, Xinghuai Sun, Yuhong Chen, Yuhong Chen   +8 more
doaj   +1 more source

Visual impairment in the hearing impaired students

Indian Journal of Ophthalmology, 2009
Ocular problems are more common in children with hearing problems than in normal children. Neglected visual impairment could aggravate educational and social disability.To detect and treat visual impairment, if any, in hearing-impaired children.Observational, clinical case series of hearing-impaired children in schools providing special education ...
Gogate Parikshit, Rishikeshi Nikhil, Mehata Reshma, Ranade Satish, Kharat Jitesh, Deshpande Madan   +5 more
openaire   +3 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Visualization Learning for Visually Impaired People [PDF]

, 2007
Virtual Environments (VE) are mainly visual experiments that exclude visually impaired people. In this paper we present an application that should allow almost everybody to "see" or at least to perceive 3D shapes. We will first describe the mandatory aspects of such an application, the tests we made and finally conclude by the results we obtained with ...
Patrick Salamin, Daniel Thalmann, Frédéric Vexo   +2 more
openaire   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Development of a machine learning model to predict low vision aid fitting for visually impaired patients

Frontiers in Medicine
BackgroundAt present, the fitting of low-vision aids (LVA) for patients globally necessitates the intervention of highly skilled ophthalmologists and certified rehabilitation specialists.
Bingfa Dai, Bingfa Dai, Pengpeng Pei, Zunqi Kan, Hai Lan, Wenwen Ye, Wenwen Ye, Yang Yu, Yang Yu, Xuelan Chen, Xuelan Chen, Yuyuan Yan, Yuyuan Yan, Ting Chen, Ting Chen, Jianqing Zheng, Jianqing Zheng, Lijuan Huang, Lijuan Huang, Jianmin Hu, Jianmin Hu   +20 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source