Results 71 to 80 of about 2,981,639 (311)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Common visual problems in children with disability [PDF]

, 2014
Children with disability are at a substantially higher risk of visual impairment (VI) (10.5% compared with 0.16%) but also of ocular disorders of all types, including refractive errors and strabismus.
Salt, A, Sargent, J
core  

Prevalence of blindness and visual impairment in Nigeria: the National Blindness and Visual Impairment Study. [PDF]

, 2008
PURPOSE: To determine the prevalence of blindness and visual impairment among adults aged > or = 40 years in Nigeria. METHODS: Multistage, stratified, cluster random sampling with probability proportional to size procedures was used to identify a cross ...
Kyari, Fatima, Entekume, Gabriel, Nigeria National Blindness and Visual Impairment Study Group, Gudlavalleti, Murthy VS, Sivsubramaniam, Selvaraj, Foster, Allen, Gilbert, Clare E, Abdull, Mohammed M   +7 more
core   +1 more source

SHP-2-Induced Activation of c-Myc Is Involved in PDGF-B-Regulated Cell Proliferation and Angiogenesis in RMECs

Frontiers in Physiology, 2020
Background: Aberrant neovascularization resulting from inappropriate angiogenic signaling is closely related to many diseases, such as cancer, cardiovascular disease, and proliferative retinopathy.
Jun Ma, Jun Ma, Wenyi Tang, Ruiping Gu, Fangyuan Hu, Fangyuan Hu, Lei Zhang, Jihong Wu, Jihong Wu, Gezhi Xu, Gezhi Xu   +10 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Visual and health outcomes, measured with the activity inventory and the EQ-5D, in visual impairment [PDF]

, 2017
Purpose Generic instruments to assess health utilities can be used to express the burden of health problems in widely used indexes. That is in contrast with what can be obtained with condition-specific instruments, outcomes are very specific and ...
Santana, Rui, Cima, Joana,, Baptista, António M. G., Joana Cima, António M. G. Baptista, Lima Ramos, Pedro,, Macedo, António Filipe, Marques, Ana Patricia,, Massof, Robert,, Moreno, Laura Hernández, Santana, Rui,, Rui Santana, Pedro Lima Ramos, Cima, Joana, Lima Ramos, Pedro, Robert Massof, Marques, Ana Patricia, Laura Hernandez-Moreno, Hernandez-Moreno, Laura, Antonio Filipe Macedo, Baptista, António M. G.,, Massof, Robert, Hernandez-Moreno, Laura,, Ramos, Pedro Alexandre Fernandes Lima, Macedo, António Filipe,, Ana Patricia Marques   +25 more
core   +1 more source

Retinal ganglion cells induce stem cell-derived neuroprotection via IL-12 to SCGF-β crosstalk

Stem Cell Research & Therapy
Background Stem cell-derived secreted factors could protect neurons in neurodegenerative disease or after injury. The exact neuroprotective components in the secretome remain challenging to discover.
Qing Xia, Kun-Che Chang, Yanan Sun, Michael Nahmou, Takahiko Noro, Yun Cheng, Xiangmei Kong, Xiaofen Mo, Jeffrey L. Goldberg, Suqian Wu   +9 more
doaj   +1 more source

Metabolic characterization of human aqueous humor in the cataract progression after pars plana vitrectomy

BMC Ophthalmology, 2018
Background While pars plana vitrectomy (PPV) has become the third most commonly performed surgery in the world, it can also induce multiple post complications easily.
Yinghong Ji, Xianfang Rong, Yi Lu
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Development of a machine learning model to predict low vision aid fitting for visually impaired patients

Frontiers in Medicine
BackgroundAt present, the fitting of low-vision aids (LVA) for patients globally necessitates the intervention of highly skilled ophthalmologists and certified rehabilitation specialists.
Bingfa Dai, Bingfa Dai, Pengpeng Pei, Zunqi Kan, Hai Lan, Wenwen Ye, Wenwen Ye, Yang Yu, Yang Yu, Xuelan Chen, Xuelan Chen, Yuyuan Yan, Yuyuan Yan, Ting Chen, Ting Chen, Jianqing Zheng, Jianqing Zheng, Lijuan Huang, Lijuan Huang, Jianmin Hu, Jianmin Hu   +20 more
doaj   +1 more source