Results 71 to 80 of about 406,069 (249)

Visual impairment is associated with physical and mental comorbidities in older adults:a cross-sectional study [PDF]

, 2014
Background<p></p> Visual impairment is common in older people and the presence of additional health conditions can compromise health and rehabilitation outcomes.
A Black, A Davis, A Marengoni, A Stuck, AH Abdelhafiz, AT Toosy, B Gopinath, BL Brody, Bruce Guthrie, BW Rovner, Daniel J Smith, EF France, G Rees, Gary McLean, HE Whitson, Helen Court, HT Vu, J Schneider, JE Crews, JE Goldstein, JM Woodhouse, JR Evans, JR Evans, K Barnett, KM Kiely, KM Sand, LE Culham, M Fortin, MJ Crawford, R Elder, R Gijsen, RJ Barry, RM van Nispen, RQ Ivers, S Schwartz, SA Haymes, SC Davies, Stewart W Mercer, TH Margrain, V Carstairs   +39 more
core   +7 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Visual impairment and multimorbidity in a representative sample of the Spanish population  [PDF]

, 2015
BACKGROUND: In the context of population aging, visual impairment has emerged as a growing concern in public health. However, there is a need for further research into the relationship between visual impairment and chronic medical conditions in the ...
Ayuso Mateos, José Luis, Garin, Noe, Haro Abad, Josep Maria, Lara, Elvira, Miret, Marta, Moneta, Maria Victoria, Olaya Guzmán, Beatriz   +6 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Metabolic characterization of human aqueous humor in the cataract progression after pars plana vitrectomy

BMC Ophthalmology, 2018
Background While pars plana vitrectomy (PPV) has become the third most commonly performed surgery in the world, it can also induce multiple post complications easily.
Yinghong Ji, Xianfang Rong, Yi Lu
doaj   +1 more source

Heterogeneity of Axenfeld–Rieger Syndrome: Molecular and Clinical Findings in Chinese Patients

Frontiers in Genetics, 2021
Axenfeld–Rieger Syndrome (ARS) is a rare disease with a wide spectrum of ocular and systemic manifestations. The genetic spectrum of Chinese patients with ARS and genotype-phenotype correlations have yet to be described.
Youjia Zhang, Youjia Zhang, Xueli Chen, Li Wang, Xinghuai Sun, Xinghuai Sun, Xinghuai Sun, Yuhong Chen, Yuhong Chen   +8 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Development of a machine learning model to predict low vision aid fitting for visually impaired patients

Frontiers in Medicine
BackgroundAt present, the fitting of low-vision aids (LVA) for patients globally necessitates the intervention of highly skilled ophthalmologists and certified rehabilitation specialists.
Bingfa Dai, Bingfa Dai, Pengpeng Pei, Zunqi Kan, Hai Lan, Wenwen Ye, Wenwen Ye, Yang Yu, Yang Yu, Xuelan Chen, Xuelan Chen, Yuyuan Yan, Yuyuan Yan, Ting Chen, Ting Chen, Jianqing Zheng, Jianqing Zheng, Lijuan Huang, Lijuan Huang, Jianmin Hu, Jianmin Hu   +20 more
doaj   +1 more source

Comparing objective visual quality impairment detection in 2D and 3D video sequences [PDF]

, 2012
The skill level of teleoperator plays a key role in the telerobotic operation. However, plenty of experiments are required to evaluate the skill level in a conventional assessment.
Staelens, Nicolas, Boussaer, Arnaud, Vercammen, Nick, Van hoogenbemt, Geert, Vermeulen, Brecht, Demeester, Piet   +5 more
core   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source