Results 121 to 130 of about 4,362,153 (359)

Disentangling How the Brain is “Wired” in Cortical/Cerebral Visual Impairment (CVI)

Seminars in Pediatric Neurology, 2017
Cortical/cerebral visual impairment (CVI) results from perinatal injury to visual processing structures and pathways of the brain and is the most common cause of severe visual impairment/blindness in children in developed countries.
L. Merabet, D. Mayer, C. Bauer, D. Wright, B. Kran   +4 more
semanticscholar   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Elderly drivers and simulated visual impairment [PDF]

, 1995
BACKGROUND. The effect of simulated visual impairment on the driving performance of elderly subjects and the relation between changes in driving performance and vision were investigated. METHODS.
Wood, Joanne M., Troutbeck, Rodney J.
core  

A New Visual Stimulation Program for Improving Visual Acuity in Children with Visual Impairment: A Pilot Study [PDF]

, 2017
The purpose of this study was to investigate the effectiveness of visual rehabilitation of a computer-based visual stimulation (VS) program combining checkerboard pattern reversal (passive stimulation) with oddball stimuli (attentional modulation) for ...
Tsai, Li-Ting; Hsu, Jung-Lung; Wu, Chien-Te; Chen, Chia-Ching; Su, Yu-Chin
core   +1 more source

A review of visual impairment

, 2018
Visual impairment (VI), a global concern that is likely to escalate with prolonged life expectancies, has gained increasing attention in the realm of eye care.
Shivani Naipal, N. Rampersad
semanticscholar   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Prevalence of Visual Impairment in Portugal : study design and initial results [PDF]

, 2015
Purpose Information about the prevalence of visual impairment is fundamental to define policies that deal with vision loss. The aim of this study is to determine the prevalence of visual impairment (VI) in the population looking for eye care in public ...
Freitas, Cristina,, Rocha-Sousa, Amandio A.,, Mendes-Ferreira, José,, Rubin, Gary S.,, Carneiro de Freitas, Rui,, Leite, Ricardo,, Macedo, António Filipe,, Sousa, Keissy,, Santana, Rui,, Soares, Andreia,   +9 more
core  

Temporal trends in the epidemiology of childhood severe visual impairment and blindness in the UK [PDF]

, 2023
BACKGROUND/AIMS: Understanding temporal trends in childhood visual disability is necessary for planning and evaluating clinical services and health policies. We investigate the changing epidemiology of severe visual impairment (SVI) and blindness (BL) in
British Childhood Visual Impairment and Blindness Study Interest, Solebo, AL, Teoh, LJ, Rahi, JS   +3 more
core  

Retinal Vascular Autoregulation during Phase IV of the Valsalva Maneuver: An Optical Coherence Tomography Angiography Study in Healthy Chinese Adults

Frontiers in Physiology, 2017
The impairment of retinal vascular autoregulation can be an early manifestation of many systemic and ocular diseases. Therefore, quantifying retinal vascular autoregulation in a non-invasive manner is very important. This study evaluated the effects of a
Yuan Zong, Yuan Zong, Huan Xu, Huan Xu, Jian Yu, Jian Yu, Chunhui Jiang, Chunhui Jiang, Chunhui Jiang, Xiangmei Kong, Xiangmei Kong, Yi He, Yi He, Xinghuai Sun, Xinghuai Sun   +14 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source