Results 131 to 140 of about 4,116,225 (362)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Online platform vs. doctors: a comparative exploration of congenital cataract patient education from virtual to reality

Frontiers in Artificial Intelligence
ObjectiveThis study aimed to assess the quality and readability of patient education on congenital cataracts provided by Google, ChatGPT, and clinical doctors. Given the rarity of congenital cataracts and the need for accessible, accurate information for
Xuanqiao Lin, Xuanqiao Lin, Xuanqiao Lin, Xuanqiao Lin, Lifang Bai, Lifang Bai, Lifang Bai, Lifang Bai, Xiaohuan Zhao, Xiaohuan Zhao, Xiaohuan Zhao, Xiaohuan Zhao, Lei Cai, Lei Cai, Lei Cai, Lei Cai, Jin Yang, Jin Yang, Jin Yang, Jin Yang   +19 more
doaj   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

Overexpression of Optic Atrophy Type 1 Protects Retinal Ganglion Cells and Upregulates Parkin Expression in Experimental Glaucoma

Frontiers in Molecular Neuroscience, 2018
Glaucoma is a neurodegenerative disease that features progressive loss of retinal ganglion cells (RGCs). Increasing evidences have revealed that impaired mitochondrial dynamics occurs early in neurodegenerative diseases.
Xinxin Hu, Xinxin Hu, Xinxin Hu, Xinxin Hu, Yi Dai, Yi Dai, Yi Dai, Yi Dai, Rong Zhang, Rong Zhang, Rong Zhang, Kunte Shang, Kunte Shang, Kunte Shang, Kunte Shang, Xinghuai Sun, Xinghuai Sun, Xinghuai Sun, Xinghuai Sun, Xinghuai Sun   +19 more
doaj   +1 more source

Ethnicity and Deprivation are Associated With Blindness Among Adults With Primary Glaucoma in Nigeria: Results From the Nigeria National Blindness and Visual Impairment Survey. [PDF]

, 2016
PURPOSE: We explored the risk factors for glaucoma blindness among adults aged 40 years and above with primary glaucoma in Nigeria. PARTICIPANTS AND METHODS: A total of 13,591 participants aged 40 years and above were examined in the Nigeria Blindness ...
Evans, Jennifer R, Gilbert, Clare E, Kyari, Fatima, Murthy, Gudlavalleti VS, Nigeria National Blindness and Visual Impairment Study Group, Wormald, Richard   +5 more
core   +2 more sources

The Prevalence and Causes of Visual Impairment and Blindness Among Older Adults in the City of Lodz, Poland

Medicine, 2015
To investigate the prevalence and causes of visual impairment and blindness in a sample of Polish older adults.The study was designed in a cross-sectional and observational manner.
M. Nowak, J. Śmigielski
semanticscholar   +1 more source

Empowering Online Adult Educators: Integrating Artificial Intelligence for Enhanced Instructional Strategies

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT This article explores how artificial intelligence (AI) can support online adult learning by aligning with Knowles’ four principles of andragogy: involvement, experience, problem‐centeredness, and relevance. Three activities were analyzed using a comparative case study (CCS) method.
Xi Lin, Steve W. Schmidt
wiley   +1 more source

Information technology and visual impairment: New developments [PDF]

, 1999
No abstract ...
Burton, Mike, Dimigen, Gisela, Roy, Archie W.N.   +2 more
core  

Morphometric analyses of the visual pathways in macular degeneration

, 2014
Introduction. Macular degeneration (MD) causes central visual field loss. When field defects occur in both eyes and overlap, parts of the visual pathways are no longer stimulated.
Baseler, Heidi A., Cornelissen, Frans W., Gouws, Andre, Greenlee, Mark W., Hernowo, Aditya T., Hooymans, Johanna M. M., Morland, Antony B., Plank, Tina, Prins, Doety   +8 more
core   +2 more sources

Longitudinal Study of Salivary Biomarkers in the Definition of Clinico‐Molecular Progression of Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
Longitudinal changes in salivary biomarkers in Parkinson’s disease (PD) from early (T0) to 4‐year follow‐up (T1), quantified by ELISA: oligomeric and total α‐synuclein, total and phosphorylated tau, MAP1LC3B (autophagy), and TNFa (inflammation). Blue arrows indicate direction of change at T1 vs T0 (up = increase; down = decrease).
Maria Ilenia De Bartolo, Daniele Belvisi, Matteo Costanzo, Claudia Caturano, Francesco Emanuele Bellomi, Carolina Cutrona, Flavia Aiello, Giorgio Leodori, Massimo Marano, Romina Mancinelli, Antonella Conte, Giovanni Fabbrini, Alfredo Berardelli, Giorgio Vivacqua   +13 more
wiley   +1 more source