Results 131 to 140 of about 4,186,077 (394)

Quality of life and visual function in Nigeria: findings from the National Survey of Blindness and Visual Impairment [PDF]

open access: yes, 2011
Aims To assess associations of visual function (VF) and quality of life (QOL) by visual acuity (VA), causes of blindness and types of cataract procedures in Nigeria. Methods Multi-stage stratified cluster random sampling was used to identify a nationally
Abubakar, T   +10 more
core   +1 more source

The Precise Diagnosis of Wolfram Syndrome Type 1 Based on Next-Generation Sequencing

open access: yesFrontiers in Genetics, 2019
Purpose: To explore a method for the early, rapid and accurate diagnosis of Wolfram syndrome 1 (WS1) and further enrich the spectrum of WFS1 mutations in the Chinese population.Methods: We analyzed 279 patients with unexplained optic atrophy using next ...
Dan-Dan Wang   +20 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

open access: yesFEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde   +3 more
wiley   +1 more source

Information technology and visual impairment: New developments [PDF]

open access: yes, 1999
No abstract ...
Burton, Mike   +2 more
core  

Online platform vs. doctors: a comparative exploration of congenital cataract patient education from virtual to reality

open access: yesFrontiers in Artificial Intelligence
ObjectiveThis study aimed to assess the quality and readability of patient education on congenital cataracts provided by Google, ChatGPT, and clinical doctors. Given the rarity of congenital cataracts and the need for accessible, accurate information for
Xuanqiao Lin   +19 more
doaj   +1 more source

Association between visual impairment and depression in the elderly: a systematic review.

open access: yesArquivos Brasileiros de Oftalmologia, 2015
A systematic review was conducted to investigate the relationship between visual impairment and depression in the elderly. We searched electronic databases (LILACS, SciELO, MEDLINE, and Cochrane Central Register of Controlled Trials) from inception to ...
Marina Viegas Moura Rezende Ribeiro   +5 more
semanticscholar   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

open access: yesAging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath   +3 more
wiley   +1 more source

Sex and weight category differences in the temporal combat structure of judokas with visual impairment [PDF]

open access: gold, 2022
Alfonso Gutiérrez-Santiago   +2 more
openalex   +1 more source

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