Results 61 to 70 of about 3,672,547 (299)

Reactome enhanced pathway visualization [PDF]

Bioinformatics, 2017
Abstract Motivation Reactome is a free, open-source, open-data, curated and peer-reviewed knowledge base of biomolecular pathways. Pathways are arranged in a hierarchical structure that largely corresponds to the GO biological process hierarchy, allowing the user to navigate from high level concepts ...
Konstantinos Sidiropoulos, Guilherme Viteri, Cristoffer Sevilla, Steven Jupe, Marissa Webber, Marija Orlic-Milacic, Bijay Jassal, Bruce May, Veronica Shamovsky, Corina Duenas, Karen Rothfels, Lisa Matthews, Heeyeon Song, Lincoln Stein, Robin Haw, Peter D'Eustachio, Peipei Ping, Henning Hermjakob, Antonio Fabregat   +18 more
openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Wiring a periscope--ocelli, retinula axons, visual neuropils and the ancestrality of sea spiders. [PDF]

, 2012
The Pycnogonida or sea spiders are cryptic, eight-legged arthropods with four median ocelli in a 'periscope' or eye tubercle. In older attempts at reconstructing phylogeny they were Arthropoda incertae sedis, but recent molecular trees placed them as the
Roland R Melzer, Hess, Martin, Martin Hess, Lehmann, Tobias, Melzer Roland R., Lehmann Tobias, Tobias Lehmann, Melzer, Roland R., Heß Martin   +8 more
core   +2 more sources

Automatic Algorithm-Aided Segmentation of Retinal Nerve Fibers Using Fundus Photographs

Journal of Imaging
This work presents an image processing algorithm for the segmentation of the personalized mapping of retinal nerve fiber layer (RNFL) bundle trajectories in the human retina.
Diego Luján Villarreal
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

The Diffusion Tensor Imaging Features in the Visual Pathways of Patients with Cavernous Sinus Meningioma Treated by Gamma Knife Radiosurgery

Current Research in MRI
Objective: The objectives of this study are to evaluate the effects of diffusion tensor imaging (DTI) on visual pathways following Gamma Knife radiosurgery (GKR) and to identify any correlations between DTI results and radiosurgery data.
Hafize Otçu Temur, Alpay Alkan, Mustafa Aziz Hatiboğlu, İsmail Yurtsever, Kerime Akdur, Özlem Toluk, Mehmet Hakan Seyithanoğlu   +6 more
doaj   +1 more source

Distinct acute zones for visual stimuli in different visual tasks in Drosophila. [PDF]

PLoS ONE, 2013
The fruit fly Drosophila melanogaster has a sophisticated visual system and exhibits complex visual behaviors. Visual responses, vision processing and higher cognitive processes in Drosophila have been studied extensively.
Xing Yang, Xing Yang, Aike Guo
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Perception, action and the cortical visual streams [PDF]

, 2005
Over a decade ago Milner and Goodale suggested that perception and action are subserved by two distinct cortical visual streams. The ventral stream projecting from striate cortex to inferotemporal cortex is involved in the perceptual identification of ...
Rice, Nichola J
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source