Results 81 to 90 of about 924,003 (290)

Distribution Coding in the Visual Pathway

Biophysical Journal, 1973
Although a variety of types of spike interval histograms have been reported, little attention has been given to the spike interval distribution as a neural code and to how different distributions are transmitted through neural networks. In this paper we present experimental results showing spike interval histograms recorded from retinal ganglion cells ...
Sanderson, A.C., Kozak, W.M., Calvert, T.W.   +2 more
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The visual word form system in context [PDF]

, 2011
According to the “modular” hypothesis, reading is a serial feedforward process, with part of left ventral occipitotemporal cortex the earliest component tuned to familiar orthographic stimuli.
Beckmann, C, Brownsett, S, Dhanjal, N, Wise, R, Woodhead, Z   +4 more
core   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Visual Pathways Serving Motion Detection in the Mammalian Brain

Sensors, 2010
Motion perception is the process through which one gathers information on the dynamic visual world, in terms of the speed and movement direction of its elements.
Alice Rokszin, Zita Márkus, Gábor Braunitzer, Antal Berényi, György Benedek, Attila Nagy   +5 more
doaj   +1 more source

Rapid motion adaptation reveals the temporal dynamics of spatiotemporal correlation between ON and OFF pathways [PDF]

, 2016
At the early stages of visual processing, information is processed by two major thalamic pathways encoding brightness increments (ON) and decrements (OFF).
A Pavan, A Pavan, A Pavan, A Pinkus, B Krekelberg, C Wehrhahn, C Wehrhahn, CH Mo, D Brainard, D Pelli, DH Hubel, DH Hubel, DM Glasser, EH Adelson, EJ Chichilnisky, G Campana, H Kafaligonul, H Kafaligonul, J Cass, JC Tuthill, JPH Van Santen, M Edwards, M Morgan, MB Mandler, MM Del Viva, MM Del Viva, MW Greenlee, P Azzopardi, P Cavanagh, PH Schiller, PH Schiller, PH Schiller, R Kanai, R Kanai, RC Emerson, RF Hess, RJ Bours, RJE Bours, RW Bowen, SJ Komban, SM Anstis, SM Anstis, T Sato, Y Benjamini, Y Benjamini, ZL Lu   +45 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Neural Pathways Conveying Novisual Information to the Visual Cortex

Neural Plasticity, 2013
The visual cortex has been traditionally considered as a stimulus-driven, unimodal system with a hierarchical organization. However, recent animal and human studies have shown that the visual cortex responds to non-visual stimuli, especially in ...
Wen Qin, Chunshui Yu
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source