Results 71 to 80 of about 23,516 (259)

Mathematical activities and critical thinking ability in Lagosi weaving process of the Buginese community

open access: yesJournal of Honai Math
Lagosi, a renowned woven fabric of national significance, involves a precise calculation formula in its manufacturing process. Craftsmen must meticulously count the threads to ensure the motif aligns with the intended design. Despite its importance, this
Hikmawati Pathuddin   +4 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Visual Encoding Approaches for Temporal Social Networks

open access: yes, 2014
Visualisations have become an inseparable part of social network analysis methodologies. However, despite the large amount of work in the field of social network visualisation there are still a number of areas in which current visualisation methods can ...
Hoek, Peter
core   +1 more source

Cases of endophthalmitis caused by Candida albicans and Candida dubliniensis identified via internal transcribed spacer deep sequencing

open access: yesBMC Ophthalmology
Background We report two cases of fungal endophthalmitis induced by Candida species identified based on internal transcribed spacer 1 (ITS1) sequencing. Case presentation In two cases, endophthalmitis was suspected, and the patients underwent pars plana ...
Kazunobu Asao   +5 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

A misjudged approach to a high accident rate : exploration of accident causes and instructor decisons relating to inexperienced glider pilots [PDF]

open access: yes, 2009
Very little research has focussed on inexperienced pilots and there is a notion in literature and popular texts that such pilots are one of the safest groups.
Jarvis, Stephen
core  

Rocky reef fish assemblage structure in coastal islands of Southern Brazil

open access: yesFrontiers in Marine Science, 2015
Rocky reef fish assemblage structure in seven coastal islands of Southern Brazil was characterized by underwater visual census (20 m x 2 m transect method 40 m2), average depth of six meters, to obtain density (fish/40 m2) and biomass (grams/40 m2). Fish
Felippe A Daros   +6 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Strategies for image visualisation and browsing

open access: yes, 2010
PhDThe exploration of large information spaces has remained a challenging task even though the proliferation of database management systems and the state-of-the art retrieval algorithms is becoming pervasive.
Janjusevic, Tijana
core  

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