Results 91 to 100 of about 3,090,801 (349)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

LMap: Shape-Preserving Local Mappings for Biomedical Visualization

, 2018
Visualization of medical organs and biological structures is a challenging task because of their complex geometry and the resultant occlusions. Global spherical and planar mapping techniques simplify the complex geometry and resolve the occlusions to aid
Gu, Xianfeng, Kaufman, Arie, Nadeem, Saad   +2 more
core   +1 more source

Impact of MRI radiomic feature normalization for prognostic modelling in uterine endometrial and cervical cancers

Scientific Reports
Widespread clinical use of MRI radiomic tumor profiling for prognostication and treatment planning in cancers faces major obstacles due to limitations in standardization of radiomic features.
Erlend Hodneland, Erling Andersen, Kari S. Wagner-Larsen, Julie A. Dybvik, Njål Lura, Kristine E. Fasmer, Mari K. Halle, Camilla Krakstad, Ingfrid Haldorsen   +8 more
doaj   +1 more source

Graphene-Based Nanoscale Vacuum Channel Transistor

Nanoscale Research Letters, 2018
We report the fabrication and electrical performance of nanoscale vacuum channel transistor (NVCT) based on graphene. Ninety-nanometer-width vacuum nano-channel could be precisely fabricated with standard electron beam lithography process.
Ji Xu, Zhuyan Gu, Wenxin Yang, Qilong Wang, Xiaobing Zhang   +4 more
doaj   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Visualizing visual literacy

, 2018
In recent times, the declaration of the prominence of the visual over other channels of communication has been persistent across several disciplines, including film studies, design, sociology, and literacy education (e.g. Bolter, 1991; Fransecky & Debes, 1972; Kress, 2005; Sartori, 1998; Messaris, 2012). It is within this loom of visuality that the
Ernesto José, Peña Alonso
openaire   +2 more sources

Use of Remote Surface Based Tools for Visualizing Integrated Brain Imaging Data [PDF]

, 2004
We describe a surface-based approach to 3D visualization of integrated neuroimaging data. Our web-enabled software allows researchers to use these visualization tools over the Internet.
Brinkley, James F, Moore, Eider B, Poliakov, Andrew V   +2 more
core   +1 more source

A Modeling Investigation on High-Speed Broad Spectrum Filtering System Based on Electric Fluid Technology

IEEE Photonics Journal, 2017
By combining advanced fluid control technology with surface plasmonic resonance phenomenon, we could take advantage of various unique characteristics of plasmonics without changing the original structure to realize a tunable color filtering system.
Jun Wu, Qiuyue Zhu, Zhiyang Qi, Jun Xia, Chenliang Chang, Qilong Wang, Baoping Wang   +6 more
doaj   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Natural Visualizations [PDF]

, 2006
This paper demonstrates the prevalence of a shared characteristic between visualizations and images of nature. We have analyzed visualization competitions and user studies of visualizations and found that the more preferred, better performing ...
Haroz, Steve, Ma, Dr. Kwan-Liu
core