Results 81 to 90 of about 3,298,081 (299)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Reliable uncertainty estimates in deep learning with efficient Metropolis-Hastings algorithms
Nature CommunicationsApproaching problems with data-driven models often requires reliable uncertainty estimates. Bayesian neural networks can offer these for deep learning models.
Matthias Schmal, Patrick Mäder
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
7 Dimensions of software change patterns
Scientific ReportsEvolving software is a highly complex and creative problem in which a number of different strategies are used to solve the tasks at hand. These strategies and reoccurring coding patterns can offer insights into the process.
Mario Janke, Patrick Mäder
doaj +1 more source
, 2020 Autonomous unmanned aerial vehicles are complex systems of hardware, software, and human input. Understanding this complexity is key to their development and operation.
Borkin, Michelle A. +4 more
core +1 more source
Visual Servoing and Visual Tracking [PDF]
, 2008 This chapter introduces visual servo control, using computer vision data in the servo loop to control the motion of a robot. We first describe the basic tech- niques that are by now well established in the field. We give a general overview of the formulation of the visual servo control problem, and describe the two archetypal visual servo control ...
Chaumette, François, Hutchinson, Seth
openaire +2 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
A Machine Learning-Based Pipeline for the Extraction of Insights from Customer Reviews
Big Data and Cognitive ComputingThe efficiency of natural language processing has improved dramatically with the advent of machine learning models, particularly neural network-based solutions. However, some tasks are still challenging, especially when considering specific domains. This
Róbert Lakatos +7 more
doaj +1 more source
Visual Imagery: Visual Format or Visual Content? [PDF]
Mind & Language, 2010 It is clear that visual imagery is somehow significantly visual. Some theorists, like Kosslyn, claim that the visual nature of visualisations derives from features of the neural processes which underlie those episodes. Pylyshyn claims, however, that it may merely reflect special features of the contents which we grasp when we visualise things.
openaire +1 more source