Results 111 to 120 of about 3,446,419 (330)

Visual Adaptation [PDF]

open access: yesAnnual Review of Vision Science, 2015
Sensory systems continuously mold themselves to the widely varying contexts in which they must operate. Studies of these adaptations have played a long and central role in vision science, partly because the specific adaptations remain a powerful tool for dissecting vision by exposing the mechanisms that are adapting. That is, “if it adapts, it's there.”
openaire   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Forum: Visualizing History, Visualizing Nation

open access: yesRethinking History, 2014
[Abstract Not Available]
openaire   +2 more sources

Draw Your Own Visualization [PDF]

open access: yes, 2003
The purpose of this activity is to learn about visualizations by designing and drawing one. Students draw a visualization based either on their interests and ideas about the world or based on actual GLOBE data.
The GLOBE Program, UCAR (University Corporation for Atmospheric Research)
core  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

On the Optimization of Visualizations of Complex Phenomena [PDF]

open access: yes, 2005
The problem of perceptually optimizing complex visualizations is a difficult one, involving perceptual as well as aesthetic issues. In our experience, controlled experiments are quite limited in their ability to uncover interrelationships among ...
Bair, Althea D   +2 more
core   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Towards Coordination-Intensive Visualization Software [PDF]

open access: yes, 2003
Most coordination realizations in current visualization systems are ''last-minute'' ad-hoc and rely on the richness of the chosen implementation language. Moreover, very few visualization models implicitly consider coordination.
Boukhelifa, Nadia   +2 more
core  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

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