FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
Safety, tolerability, and impact on allergic inflammation of autologous E.coli autovaccine in the treatment of house dust mite asthma - a prospective open clinical trial [PDF]
, 2011 Background: Asthma is increasing worldwide and results from a complex immunological interaction between genetic susceptibility and environmental factors. Autovaccination with E.
AE Wright +25 more
core +3 more sources
FEBS Open Bio, EarlyView.Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui +15 more
wiley +1 more source
Phenotyping Clusters of Patient Trajectories suffering from Chronic Complex Disease [PDF]
arXiv, 2020 Recent years have seen an increased focus into the tasks of predicting hospital inpatient risk of deterioration and trajectory evolution due to the availability of electronic patient data. A common approach to these problems involves clustering patients time-series information such as vital sign observations) to determine dissimilar subgroups of the ...
arxiv
Professional Development: COLA 100L
, 2019 The need for professional development integration into curriculum is vital for student success. Colleges and universities across the country are implementing career and professional development opportunities into classroom curriculum to better prepare ...
Moore, Kassandra
core
Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies
Aging and Cancer, EarlyView.This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal +8 more
wiley +1 more source
Single-cell RNA sequencing of intestinal crypts reveals vital events in damage repair and the double-edged sword effect of the Wnt3/β-catenin pathway in irradiated mice. [PDF]
Redox Biol, 2023 Yuan T, Zhang J, Zhao Y, Guo Y, Fan S.
europepmc +1 more source
Evaluation of a village-informant driven demographic surveillance system in Karonga, Northern Malawi [PDF]
This paper describes and evaluates the first demographic surveillance system (DSS) in Malawi, covering a rural population of 30,000. Unlike others, the Karonga DSS relies on trained village informants using formatted registers for the primary ...
Amelia Crampin +9 more
core
White Christian Nationalism: Adult Education and Threats to Democracy
New Directions for Adult and Continuing Education, EarlyView.ABSTRACT Adult education has a historical and ongoing commitment to fostering democratic relationships, demonstrated by the tendency of adult education to be called upon when social change and realignment are most desirable. This article considers the philosophical and pragmatic possibilities for adult education at this moment, when White Christian ...
Ralf St. Clair, Lyn Tett, Rob Black
wiley +1 more source
Matching Neuromorphic Events and Color Images via Adversarial Learning [PDF]
arXiv, 2020 The event camera has appealing properties: high dynamic range, low latency, low power consumption and low memory usage, and thus provides complementariness to conventional frame-based cameras. It only captures the dynamics of a scene and is able to capture almost "continuous" motion.
arxiv