Results 31 to 40 of about 4,117 (224)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Estresores vitales durante la infancia y trastorno de ansiedad: una meta-revisión
Duazary, 2018 Está bien establecido que los estresores vitales durante la infancia, en particular el abuso sexual, se asocian a trastorno de ansiedad y trastorno de estrés postraumático; sin embargo, se cuenta con menor información sobre la relación entre las ...
Edwin Herazo +2 more
doaj
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Praxis Educativa, 2021 Se abordan trayectorias vitales y educativas, redes personales, obstáculos y logros de tres mujeres que, siendo titulares de un plan social, obtuvieron un título universitario en una carrera de corte social.
Flavia Arrigoni +2 more
doaj
, 2011 Vitalism is typically presented as the belief – scientific, metaphysical, poetic and other – in the uniqueness of Life, presented as a ‘substance’, ‘force’, or ‘principle’. As such it is a frequently criticized theory, often in caricatural forms, where a model of the living being (notably of organism), embryo development, or forms of non-mechanical ...
openaire +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Álabe, 2014 Considero que la estética es una de las maneras de configurar la imagen del “yo-soy-libre porque he nacido libre por naturaleza”. Que es a su vez el eje del inconsciente ideológico/ libidinal del capitalismo.
Juan Carlos Rodríguez
doaj +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source