Results 61 to 70 of about 335,899 (324)
Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
Acontecimientos vitales estresantes, estilo de afrontamiento y ajuste adolescente. Un análisis longitudinal de los efectos de moderación [PDF]
, 2012 El objetivo principal de este estudio fue analizar la relación entre la vivencia de los acontecimientos vitales estresantes y los problemas de ajuste emocional y comportamental durante la adolescencia, prestando atención al posible efecto moderador del ...
Estévez Campos, Rosa Mª +2 more
core +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Metas vitales en estudiantes argentinos
Revista de Psicología, 2019 Se presentan los resultados de un trabajo empírico en el que, en una muestra de 475 estudiantes en el rango de 17 a 55 años, se aplicó el Cuestionario de metas de Nurmi (1989b), con los objetivos de explorar diferencias en el contenido, densidad ...
Stella Maris Vázquez +2 more
doaj
Nature, 1908 I HAVE in my possession a sprig of Bryophyllum calycinum which was cut off a plant in Jamaica six months ago, at the beginning of June. It has still attached to it three leaves, which are quite green, and at the edges of these there are minute new shoots projecting from the crenations.
openaire +3 more sources
Life events and general health in the Andalusian population [PDF]
, 2009 Congreso celebrado en Tarragona los días 1, 2 y 3 de octubre de 2009Los estudios epidemiológicos han puesto de manifiesto que ciertos hechos biográficos son susceptibles de provocar una enfermedad.
León Rubio, José María +2 more
core
Molecular Oncology, EarlyView.Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan +4 more
wiley +1 more source