Results 61 to 70 of about 11,774 (289)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Review of: Robert Mitchell, Experimental Life: Vitalism in Romantic Science and Literature [PDF]
, 2015 Review by Jan Golinski (University of New Hampshire) of Robert Mitchell, Experimental Life: Vitalism in Romantic Science and Literature. Baltimore: Johns Hopkins University Press, 2013. Pp. 309.
Golinski, Jan V.
core +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Bajo Palabra, 2017 El presente trabajo es una reflexión ensayística sobre la construcción de Julio Iglesias como arquetipo musical e intérprete de canciones propias del vitalismo burgués en el régimen visual del siglo XX.Palabras clave: Julio Iglesias, burguesía, vitalismo,
José Antonio Guillén Berrendero
doaj
LIFE AS EMERGENT AGENTIAL SYSTEMS: TENDENCIES WITHOUT TELEOLOGY IN AN OPEN UNIVERSE
Zygon, 2013 Life is a relationship among various kinds of agents interacting at different scales in ways that are multifarious, complex, and emergent. Life is always a part of an ecological embedding in communities of interaction, which in turn structure and ...
doaj +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Materiality and Satire in Marvell’s “The Last Instructions to a Painter”
Marvell Studies, 2020 In “The Last Instructions to a Painter,” Marvell articulates and then critiques the idealizing ethos of the Stuart regime by using a rhetoric of corporeality to reveal the limitations and falsity of this ideological vision, and to censure the corruption ...
William Fitzhenry
doaj +2 more sources
, 2011 Vitalism is typically presented as the belief – scientific, metaphysical, poetic and other – in the uniqueness of Life, presented as a ‘substance’, ‘force’, or ‘principle’. As such it is a frequently criticized theory, often in caricatural forms, where a model of the living being (notably of organism), embryo development, or forms of non-mechanical ...
openaire +2 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Persona y Derecho, 1970 El Testamento vital, término convencional que recogemos pese a no ser aceptado en la legislación española, aspira a mantener la ilusión de control autónomo sobre la gestión de la enfermedad. A su vez, el testamento vital eutanásico aparece como el argumento que permitiría vincular autonomía con aceptación del homicidio eutanásico.
Serrano, J.M. (José Miguel) +1 more
openaire +3 more sources