Results 61 to 70 of about 1,287 (253)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
De la palabra al género: un itinerario
Filología, 2014 La obra de Ana María Barrenechea se caracteriza por una atención a los modos de leer. Aquí se propone, más allá de las adhesiones disciplinares y a partir de unas determinadas experiencias de trabajo (es decir: de vida comunitaria) una relectura de la ...
Daniel Link
doaj
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
La conception ternaire corps/esprit/âme dans la pensée médicale au cours des âges
Cahiers d'Études du Religieux- Recherches Interdisciplinaires, 2013 The progressive emergence of a rational medical knowledge did not prevent links with philosophy (mainly Plato and Aristotle) and theology. The tripartition body/soul/spirit (the meaning of these terms varying according to the different periods) is one of
Thierry Lavabre-Bertrand
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Do psíquico ao somático: notas sobre a reconfiguração do self contemporâneo
História, Ciências, Saúde: ManguinhosResumo O artigo examina a passagem de uma compreensão psicológica da pessoa para uma compreensão somática/cerebral. A discussão centra-se na dualidade que marca a cultura ocidental moderna, entre a visão iluminista e racionalista do mundo e a visão ...
Jane Russo
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source