Results 61 to 70 of about 3,763 (272)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Vitalism without Metaphysics? Medical Vitalism in the Enlightenment Introduction [PDF]
, 2008 il s'agit d'un numéro spécial de revue que j'ai coordonnéInternational audienceTable of contents of Science in Context vol. 21, # 4, 2008VITALISM WITHOUT METAPHYSICS? MEDICAL VITALISM IN THE ENLIGHTENMENTGuest Editor, Charles T.
Wolfe, Charles,
core +1 more source
Le parti pris des choses : sur quelques apories onto-épistémiques du New Materialism
Socio-anthropologieThe theoretical movement known as New Materialism, which emerged in the early 2000s, saw not only the return of ontology, but also the affirmation of a materialism in which all oppositions and contradictions would dissolve.
Charles Wolfe
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Vitalism in Early Modern Medical and Philosophical Thought [PDF]
, 2020 Vitalism is a notoriously deceptive term. It is very often defined as the view, in biology, in early modern medicine and differently, in early modern philosophy, that living beings differ from the rest of the physical universe due to their possessing an ...
Wolfe, Charles +2 more
core +1 more source
Materiality and Satire in Marvell’s “The Last Instructions to a Painter”
Marvell Studies, 2020 In “The Last Instructions to a Painter,” Marvell articulates and then critiques the idealizing ethos of the Stuart regime by using a rhetoric of corporeality to reveal the limitations and falsity of this ideological vision, and to censure the corruption ...
William Fitzhenry
doaj +2 more sources
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Epigênese e epigenética: as muitas vidas do vitalismo ocidental
Horizontes AntropológicosResumo A análise da história e dos usos contemporâneos dos termos epigênese, atribuído a Aristóteles, e epigenética, criado no século XX pelo biólogo C. H.
Gláucia Silva +1 more
doaj +1 more source
Canguilhem and the Logic of Life
Transversal: International Journal for the Historiography of Science, 2018 In this paper we examine aspects of Canguilhem’s philosophy of biology, concerning the knowledge of life and its consequences on science and vitalism. His concept of life stems from the idea of a living individual, endowed with creative subjectivity and ...
Arantza Etxeberria, Charles T. Wolfe
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Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source