Results 61 to 70 of about 510,546 (297)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Vitalism

, 2011
Vitalism is typically presented as the belief – scientific, metaphysical, poetic and other – in the uniqueness of Life, presented as a ‘substance’, ‘force’, or ‘principle’. As such it is a frequently criticized theory, often in caricatural forms, where a model of the living being (notably of organism), embryo development, or forms of non-mechanical ...
openaire   +2 more sources

Building the Global Sisterhood: Measurement, Evaluation and Learning Report for the Conrad N. Hilton Foundation's Catholic Sisters Initiative Strategy [PDF]

, 2015
The Conrad N. Hilton Foundation Catholic Sisters Initiative launched a five-year strategy in February 2013 to enhance the vitality of Catholic sisters, who in turn advance human development around the globe. The Sisters Initiative aims to support efforts

core  

Motivational profiles and their relationships with basic psychological needs, academic performance, study strategies, self-esteem, and vitality in dental students in Chile [PDF]

, 2018
Purpose To determine dental students’ motivational profiles through a person-centred approach and to analyse the associations with the satisfaction of their basic psychological needs, study strategies, academic performance, self-esteem, and vitality ...
Cesar A. Orsini, Field, Geraldo, Jorge A. Tricio, Leon, Orsini, Rojas-Barahona, Ryan, Vivian I. Binnie   +8 more
core   +3 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Feasibility of a home-based interdisciplinary rehabilitation program for patients with Post-Intensive Care Syndrome: the REACH study

Critical Care, 2021
Background Survivors of critical illness experience long-term functional challenges, which are complex, heterogeneous, and multifactorial in nature. Although the importance of rehabilitation interventions after intensive care unit (ICU) discharge is ...
Mel E. Major, Daniela Dettling-Ihnenfeldt, Stephan P. J. Ramaekers, Raoul H. H. Engelbert, Marike van der Schaaf   +4 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Testamentos vitales [PDF]

Persona y Derecho, 1970
El Testamento vital, término convencional que recogemos pese a no ser aceptado en la legislación española, aspira a mantener la ilusión de control autónomo sobre la gestión de la enfermedad. A su vez, el testamento vital eutanásico aparece como el argumento que permitiría vincular autonomía con aceptación del homicidio eutanásico.
Serrano, J.M. (José Miguel), Serrano, J.M. (José Miguel)   +1 more
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

‘This is the core of what we do’: a qualitative study of social prescribers’ attitudes towards spiritual health training and their future training needs

BMC Primary Care
Background Despite the evidence supporting the importance of spiritual health to people’s wellbeing across diverse fields of treatment, the topic of spiritual health is not currently mentioned in National Health Service (NHS) training materials for ...
Mark Adley, Alexandra Thompson, Philip Mordue, Amy O’Donnell, Barbara Hanratty, Ishbel Orla Whitehead   +5 more
doaj   +1 more source