Results 141 to 150 of about 1,446,129 (349)
Advanced Science, EarlyView.Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann +26 more
wiley +1 more source
Immunohistochemical Detection of the Presence of Vitamin D Receptor in Childhood Solid Tumors [PDF]
, 2022 Orsolya Juhász +4 more
openalex +1 more source
Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis
Advanced Science, EarlyView.Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang +16 more
wiley +1 more source
MR1 presents vitamin B6–related compounds for recognition by MR1-reactive T cells [PDF]
Mitchell P. McInerney +21 more
openalex +1 more source
Disparities in Head and Neck Cancer: A Case for Chemoprevention with Vitamin D [PDF]
, 2020 Mirela Ibrahimovic +7 more
openalex +1 more source
Decreased bioavailability of vitamin D in obesity.
American Journal of Clinical Nutrition, 2000 J. Wortsman +4 more
semanticscholar +1 more source
Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors
Advanced Science, EarlyView.Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen +4 more
wiley +1 more source
Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease.
New England Journal of Medicine, 1996 G. Omenn +13 more
semanticscholar +1 more source