Results 241 to 250 of about 14,407,068 (395)

Molten‐Salt‐Mediated Synthesis of Atomic Manganese/Cobalt Catalysts on Bioceramic Microparticles for Catalytic Anti‐Osteoarthritis Treatments

open access: yesAdvanced Science, EarlyView.
Microparticle‐based antioxidants capable of scavenging multiple reactive oxygen species (ROS) have been developed. When retained within the articular cavity of osteoarthritic mice, Mn‐ or Co‐AKT‐MPs protect the inherent homeostasis between cartilage anabolism and catabolism, and inhibit synovial inflammation.
Ronghui Deng   +11 more
wiley   +1 more source

Monitoring the Dynamics of Alzheimer's Disease Biomarkers and the APOE–Tau Axis via Human Cerebral Organoids with Immuno‐SERS

open access: yesAdvanced Science, EarlyView.
Noninvasive and sensitive detection of tau protein dynamics across developmental stages and APOE genotypes remain a challenge in Alzheimer's disease (AD) research. This study reveals the dynamics of tau secretion in label‐free manner using surface‐enhanced Raman spectroscopy (SERS) and human cerebral organoids (hCOs). This study provides novel insights
Yongjae Jo   +11 more
wiley   +1 more source

ZDHHC12 Palmitoylates HDAC8 to Promote the Progression of Hepatocellular Carcinoma Associated with a Diet High in Saturated Fatty Acids

open access: yesAdvanced Science, EarlyView.
This study identifies ZDHHC12 as a critical mediator of PA‐induced HCC progression. Mechanistically, PA upregulates ZDHHC12 expression through SMARCA4 activation, leading to HDAC8 palmitoylation at Cys244 which blocks HSC70‐mediated lysosomal degradation of HDAC8, thereby promoting HCC development. These findings provide novel mechanistic insights into
Xin Jin   +7 more
wiley   +1 more source

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