Results 41 to 50 of about 506,491 (309)

Involvement of Spermidine in the Reduced Lifespan of Caenorhabditis elegans During Vitamin B₁₂ Deficiency

Metabolites, 2019
Vitamin B12 deficiency leads to various symptoms such as neuropathy, growth retardation, and infertility. Vitamin B12 functions as a coenzyme for two enzymes involved in amino acid metabolisms.
Tomohiro Bito, Naho Okamoto, Kenji Otsuka, Yukinori Yabuta, Jiro Arima, Tsuyoshi Kawano, Fumio Watanabe   +6 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Proxy markers of serum retinol concentration, used alone and in combination, to assess population vitamin A status in Kenyan children: a cross-sectional study [PDF]

, 2015
Background Serum retinol concentration determined by high-performance liquid chromatography (HPLC) is recommended by the World Health Organization to assess population vitamin A status.
Inge D Brouwer, Verhoef, H., Elise F Talsma, Alida Melse-Boonstra, Brouwer, Inge D, Hulshof, Paul JM, Talsma, E.F., Anne S Mburu-de Wagt, Paul JM Hulshof, Hans Verhoef, Talsma, Elise F, Mburu-de Wagt, Anne S, Melse-Boonstra, Alida, Brouwer, I.D., Hulshof, P.J.M., Mburu-de Wagt, A.S., Verhoef, Hans, Boonstra, A.   +17 more
core   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Vitamin A and iron supplementation of Indonesian pregnant women benefits vitamin A status of their infants

, 2001
Many Indonesian infants have an inadequate nutritional status, which may be due in part to inadequate maternal nutrition during pregnancy. This study was designed to investigate whether infant nutritional status could be improved by maternal vitamin A ...
Muslimatun, S., West, C.E., Schultink, W., Schmidt, M.K., Hautvast, J.G.A.J.   +4 more
core   +1 more source

Natural Variation in Vitamin B(1) and Vitamin B(6) Contents in Rice Germplasm. [PDF]

, 2022
peer reviewedInsufficient dietary intake of micronutrients contributes to the onset of deficiencies termed hidden hunger-a global health problem affecting approximately 2 billion people.
Mangel, Nathalie, Fitzpatrick, Thérésa Bridget, Gruissem, Wilhelm, Fitzpatrick, Teresa B., Fudge, Jared, Vanderschuren, Hervé, Fudge, Jared B., Fudge, Jared B, Fitzpatrick, Teresa B   +8 more
core   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Vitamin A supplementation in Tanzania: the impact of a change in programmatic delivery strategy on coverage. [PDF]

, 2006
BACKGROUND\ud \ud Efficient delivery strategies for health interventions are essential for high and sustainable coverage. We report impact of a change in programmatic delivery strategy from routine delivery through the Expanded Programme on Immunization (
Honorati Masanja, Mugyabuso, Joseph K L, de Savigny, Don, Masanja Honorati, Mshinda Hassan M, de Savigny Don, Joanna Armstrong Schellenberg, Meera Shekar, Masanja, Honorati, Schellenberg, Joanna Armstrong, Ndossi, Godwin D, Schellenberg Joanna, Mugyabuso Joseph KL, Ndossi Godwin D, Don de Savigny, Mshinda, Hassan M, Mugyabuso, Joseph KL, Hassan M Mshinda, Godwin D Ndossi, Shekar, Meera, Joseph KL Mugyabuso, Shekar Meera   +21 more
core   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source