Results 191 to 200 of about 126,193 (275)

Hcfc1 and Ogt Mediate Zebrafish CNS Regeneration Through Hippo/Yap Signalling

Cell Proliferation, EarlyView.
This work identifies Hcfc1 and Ogt as key regulators of zebrafish CNS regeneration through modulation of Hippo/Yap signalling. Loss of Hcfc1 or Ogt activity inhibition impairs regeneration, which is restored by Yap overexpression, revealing a new regulatory axis that enhances CNS regenerative capacity.
Priyanka P. Srivastava, Sidharth Bhasin, Poonam Sharma, Omkar Mahadeo Desai, Kshitiz Yadav, Ayushma, Rohan Chakraborty, Suhel Parvez, Rajesh Ramachandran, Shilpi Minocha   +9 more
wiley   +1 more source

Host-Gut Microbiota Interactions: Exploring the Potential Role of Vitamin B1 and B2 in the Microbiota-Gut-Brain Axis and Anxiety, Stress, and Sleep Quality. [PDF]

Nutrients
Tao Y, Wu M, Su B, Lin H, Li Q, He Y, Zhong T, Xiao Y, Yu X.   +8 more
europepmc   +1 more source

Wealth inequality and epidemics in the Republic of Venice (1400–1800)

The Economic History Review, EarlyView.
Abstract This article analyses wealth inequality in the Republic of Venice during 1400–1800. The availability of a large database of homogeneous inequality measurements allows us to produce the most in‐depth study of the factors affecting inequality at the local level available thus far for any preindustrial society.
Guido Alfani, Matteo Di Tullio, Mattia Fochesato   +2 more
wiley   +1 more source

Haploinsufficiency of brain‐specific kinase BRSK1 causes epilepsy and neurodevelopmental disorders

Epilepsia, EarlyView.
Abstract Objective The BRSK1 gene encodes brain‐specific serine/threonine kinase 1 (also known as SAD‐B kinase), which is almost exclusively expressed in the brain and plays critical roles in neuronal polarization, neurotransmitter release, mitochondrial dynamics, and neuronal maturation.
Qi Zhang, Hiroshi Yamanaka, Ping Li, Yingfeng Li, Tian Luo, Miao Xia, Ting Liu, Xueyan Liu, Qing Lu, Bin Yang, Fan He, Kaixian Du, Yousheng Shu, Bo Peng, Yong‐hui Jiang, Yi Wang   +15 more
wiley   +1 more source

Archaic introgression contributed to the pre-agriculture adaptation of vitamin B1 metabolism in East Asia. [PDF]

iScience, 2022
Ma X, Xu S.
europepmc   +1 more source

FLUCTUATION OF VITAMIN-B1 IN BLOOD AND IN THE ORGAN OF CORTI FOLLOWING THE EXPOSURE TO NOISE

, 1966
SHOHEL ABIKO
openalex   +2 more sources

Residual flexibility in the topologically constrained multivalent complex between the GKAP scaffold and LC8 hub proteins

The FEBS Journal, EarlyView.
The scaffold protein GKAP and the hub protein LC8 form a well‐defined hexameric complex, with the stoichiometry of 2 GKAP : 2 LC8 dimers. NMR and molecular dynamics calculations confirm that the LC8‐binding segment of GKAP is intrinsically disordered even in the complex form.
Eszter Nagy‐Kanta, Zsófia E. Kálmán, Helena Tossavainen, Tünde Juhász, Fanni Farkas, József Hegedüs, Melinda Keresztes, Tamás Beke‐Somfai, Zoltán Gáspári, Perttu Permi, Bálint Péterfia   +10 more
wiley   +1 more source

Clinical study on the application of acupoint injection therapy with vitamin B1 in patients with diabetic peripheral neuropathy

, 2019
Ran-Hui Kang, O Kwang-Chun
openalex   +1 more source

Butyrate suppresses mucosal inflammation in inflammatory bowel disease primarily through HDAC3 inhibition in monocytes and macrophages

The FEBS Journal, EarlyView.
Butyrate mitigates intestinal inflammation in IBD. It does so primarily by suppressing pro‐inflammatory cytokines and costimulatory molecules in activated monocytes and macrophages, concomitant with enhancing pathogen clearance. In human colonic organoids, butyrate promotes epithelial expression of key genes involved in barrier function and immune ...
Daniela Parada‐Venegas, Marjorie De la Fuente López, Karen Dubois‐Camacho, Glauben Landskron, Tjasso Blokzijl, Héctor Molina, María‐Celeste Casanova, Yingying Cui, Moting Liu, Antonio M. Da Costa De Pina, Daniela Simian, María‐Julieta González, Rinse K. Weersma, Rodrigo Quera, Gerard Dijkstra, Klaas Nico Faber, Marcela A. Hermoso   +16 more
wiley   +1 more source

Dietary supplementation of vitamin B1 prevents the pathogenesis of osteoarthritis. [PDF]

Proc Natl Acad Sci U S A
Shen S, Liang Y, Zhao Y, Hu Z, Huang Y, Wu Y, Liu Y, Fan S, Wang Q, Xiao P.   +9 more
europepmc   +1 more source