Quantitative Biology, Volume 13, Issue 4, December 2025.Abstract Cancer is a complex and heterogeneous disease characterized by various genetic and epigenetic alterations. Early diagnosis, accurate subtyping, and staging are essential for effective, personalized treatment and improved survival rates. Traditional diagnostic methods, such as biopsies, are invasive and carry operational risks that hinder ...
Ezgi Tanıl, Emrah Nikerel
wiley +1 more source
Sex as a modifier of genetic risk for type 1 diabetes
Diabetes, Obesity and Metabolism, Volume 27, Issue 12, Page 6857-6868, December 2025.Abstract Sex differences influence the pathogenesis of type 1 diabetes (T1D), yet most genetic studies have treated sex as a control covariate rather than a dynamic effect modifier. Sex influences immune cell behaviour, including CD4+ and CD8+ T cell activation, regulatory T cell stability, B cell autoantibody production, dendritic cell priming and ...
Hui‐Qi Qu, Hakon Hakonarson
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Assessment of the feed additives thiamine hydrochloride (3a820) and thiamine mononitrate (3a821) (vitamin B<sub>1</sub>) for all animal species for the renewal of their authorisation (DSM Nutritional Products Ltd. and Orffa Additives BV). [PDF]
EFSA JEFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) +25 more
europepmc +1 more source
Atypical Frontotemporal Dementia Associated With SQSTM1 Gene Mutation: A Clinicopathological Case
Neuropathology, Volume 45, Issue 6, December 2025.ABSTRACT A 78‐year‐old man presented with a six‐year history of progressive memory decline, initially manifesting as recent memory impairment and mild anomia, which gradually evolved into motor clumsiness, gait disturbances, language difficulties, behavioral changes, and late‐onset parkinsonism. He had been diagnosed with Paget disease of bone (PDB) at
Christian Espinoza‐Vinces +8 more
wiley +1 more source
Feasibility, safety and effectiveness of prednisolone and vitamin B1, B6, and B12 in patients with post-COVID-19-syndrome (PreVitaCOV) - protocol of a randomised, double-blind, placebo-controlled multicentre trial in primary care (phase IIIb). [PDF]
BMC Infect DisTengelmann C +14 more
europepmc +1 more source
Veterinary Dermatology, Volume 36, Issue 6, Page 723-787, December 2025.Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis +9 more
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The Composite Antiadhesion Barrier Facilitated Fibroblast Autophagy Activation for Tendon Repair
Advanced Science, Volume 12, Issue 41, November 6, 2025.Synthesis of an innovative three‐layer composite antiadhesion barrier (plasmid DNA@E–H–E′) is schematically illustrated, highlighting its reactive‐oxygen‐species‐responsive, unidirectional interleukin‐37 delivery to enhance fibroblast autophagy, thereby effectively preventing tendon adhesion and promoting scarless tendon repair.
Zhenyu Sun +5 more
wiley +1 more source
Benfotiamine, a Lipid-Soluble Derivative of Vitamin B<sub>1</sub>, Ameliorates the Carbohydrate Overload-Induced Mitochondrial Dysfunction in Fish <i>Megalobrama amblycephala</i> by Triggering the ULK1-Mediated Mitophagy. [PDF]
Aquac NutrZhang L +6 more
europepmc +1 more source
Associations between the measures of physical function, the risk of falls and nutritional status of haemodialysis patients : a cross-sectional study [PDF]
, 2019 Calders, Patrick +6 more
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