Results 121 to 130 of about 797,518 (380)

Vitamin B12 deficiency without anemia in the middle- and old-aged population in Sulaymaniyah City

Medical Journal of Babylon, 2020
Background: In our laboratory, we received many cases of Vitamin B12 deficiency without anemia, and we observed that the deficiency is more prominent in females than males.
Hisham Arif Getta
doaj   +1 more source

Measuring and tracking vitamin B12: a review of current methods with a focus on optical spectroscopy [PDF]

, 2017
Published online: 13 Sep 2016Vitamin B12 deficiency has been associated with an increased risk of cognitive decline. This literature review explores the current methods available for measuring vitamin B12 in human blood, serum, and urine, and the need ...
Brooks, J., Hutchinson, M., Schartner, E., Tsiminis, G.   +3 more
core   +1 more source

Metabolic engineering of Escherichia coli for de novo biosynthesis of vitamin B12

bioRxiv, 2018
The only known source of vitamin B12 (adenosylcobalamin) is from bacteria and archaea. Here, using genetic and metabolic engineering, we generate an Escherichia coli strain that produces vitamin B12 via an engineered de novo aerobic biosynthetic pathway.
Huan Fang, Dong Li, Jie Kang, Pingtao Jiang, Jibin Sun, Dawei Zhang   +5 more
semanticscholar   +1 more source

Nanostructured drug delivery systems for posterior segment eye diseases: Strategies to defy ocular barriers

BMEMat, EarlyView.
Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen, Ying Yao, Yan Zhang, Xinyu Shi, Ling Bai, Yang Zhong, Yan Zhang, Kun Zhang   +7 more
wiley   +1 more source

Effect of Serum Vitamin B12 Levels on Brain Volumes

Current Research in MRI
Objective: To research the relationship between brain volumes and serum vitamin B12 markers. Methods: To investigate the volume changes of serum vitamin B12 markers in brain magnetic resonance imaging measurements of 62 participants admitted to the
Hatice Cakir, Mukadder Sunar, Ozlem Celik Aydin, Osman Kagan Cakir   +3 more
doaj   +1 more source

Association between metformin use and vitamin B12 deficiency in patients with type 2 diabetes

Mìžnarodnij Endokrinologìčnij Žurnal, 2019
Metformin is one of the most widely used oral antihyperglycemic agents. Adverse effect of metformin is disturbance in vitamin B12 metabolism associated with low serum vitamin B12 level. Vitamin B12 hypovitaminosis is accompanied by peripheral neuropathy.
V.I. Pankiv
doaj   +1 more source

Homocysteine plasma levels in patients treated with antiepileptic drugs depend on folate and vitamin B12 serum levels, but not on genetic variants of homocysteine metabolism [PDF]

, 2017
Background: Antiepileptic drugs (AEDs) are commonly used in the treatment of epilepsy, psychiatric diseases and pain disorders. Several of these drugs influence blood levels of folate and vitamin B12 and, consequently, homocysteine.
Elger, Christian, Linnebank, Michael, Moskau-Hartmann, Susanna, Semmler, Alexander, Stoffel-Wagner, Birgit   +4 more
core  

Vitamin B12 Status Upon Short-Term Intervention with a Vegan Diet—A Randomized Controlled Trial in Healthy Participants

Nutrients, 2019
Vegans are at an increased risk for certain micronutrient deficiencies, foremost of vitamin B12. Little is known about the short-term effects of dietary change to plant-based nutrition on vitamin B12 metabolism. Systemic biomarkers of vitamin B12 status,
Ann-Kathrin Lederer, L. Hannibal, Manuel Hettich, Sidney Behringer, U. Spiekerkoetter, C. Steinborn, C. Gründemann, A. Zimmermann-Klemd, Alexander Müller, T. Simmet, Michael Schmiech, A. Maul‐Pavicic, Y. Samstag, R. Huber   +13 more
semanticscholar   +1 more source

Cobalamin‐Dependent Aryl Methyl Ether O‐Demethylases: Promising Enzymes for Biocatalytic Applications from Lignin Valorization to Organic Synthesis

ChemCatChem, EarlyView.
Cobalamin‐dependent aryl methyl ether O‐demethylases have high potential for biocatalytic applications, including lignin valorization and synthetic chemistry. In this review, we provide a detailed overview of such O‐demethylase systems identified to date from various microorganisms, including their mechanism, substrate scope and selectivity, and ...
Niels Krabbe Johnsen, Santipap Chaiyasarn, Zheng Guo, Jaehong Han, Bekir Engin Eser   +4 more
wiley   +1 more source

Multivariate modular metabolic engineering and medium optimization for vitamin B12 production by Escherichia coli

Synthetic and Systems Biotechnology
Vitamin B12 is a complex compound synthesized by microorganisms. The industrial production of vitamin B12 relies on specific microbial fermentation processes. E.
Feitao Chen, Huan Fang, Jianghua Zhao, Pingtao Jiang, Huina Dong, Ying Zhao, Huiying Wang, Tongcun Zhang, Dawei Zhang   +8 more
doaj   +1 more source