Results 131 to 140 of about 424,620 (246)

Five Decades of Dispute: A Triptych. E. J. Corey

open access: yesThe Chemical Record, EarlyView.
In his 2004 Priestley Medal address, E. J. Corey stated, “On May 4, 1964, I suggested to my colleague R. B. Woodward a simple explanation involving the symmetry of the perturbed (HOMO) molecular orbitals for the stereoselective cyclobutene/1,3‐butadiene and 1,3,5‐hexatriene/cyclohexadiene conversions that provided the basis for the further development ...
Jeffrey I. Seeman
wiley   +1 more source

The role of the host—Neutrophil biology

open access: yesPeriodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple   +4 more
wiley   +1 more source

Exposure to Structurally Related Organophosphate Esters Elicits Distinct Metabolomic Perturbations in Daphnia magna

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT Organophosphate esters (OPEs) are found ubiquitously in the environment and exposure to these chemicals has induced behavioral, developmental, and morphological impairments in several model organisms. Yet there is still a lack of understanding of how sub‐lethal exposure disrupts organism function at the molecular‐level, especially for Daphnia ...
Salwa Hajir   +4 more
wiley   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

open access: yesVIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

From foraging to decomposition: Large vertebrates as biotic drivers of trace element cycling across landscapes

open access: yesJournal of Animal Ecology, EarlyView.
We highlight an overlooked pathway in ecosystem functioning: the role of animal carcass decomposition in trace element cycling. By linking animal life cycles to landscape‐scale processes, we explain how large animals redistribute scarce elements and influence spatial heterogeneity, with implications for ecosystem functioning and restoration.
Elke Wenting   +6 more
wiley   +1 more source

Ultra‐Processed Food Consumption and Childhood Allergic Diseases: Increased Risk of Asthma Onset in the SENDO Project

open access: yesAllergy, EarlyView.
The SENDO cohort study (2015–2024) prospectively analyzed the impact of ultra‐processed food (UPF) consumption on asthma and atopy in 1,546 Spanish children. Higher UPF intake (NOVA 4 classification) was significantly associated with an increased risk of asthma but not atopy, atopic dermatitis, neumoallergen sensitation, food allergy over five years ...
O. Galindo   +6 more
wiley   +1 more source

Distinct Skin Penetration and Immune Responses to Ionic and Nanoparticulate Cobalt in Allergic Contact Dermatitis

open access: yesAllergy, EarlyView.
Cobalt chloride (CoCl2) and cobalt nanoparticles (CoNPs) induce a shared, severity‐dependent inflammatory response in cobalt‐sensitized skin characterized by activation of interferon signaling, inflammatory pathways (TNF/NF‐κβ, IL6‐STAT3), apoptosis/UPR, cell cycle programs, and glycolysis.
Paulina Werner   +8 more
wiley   +1 more source

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