Results 1 to 10 of about 1,234 (191)

Holotranscobalamin Is a Useful Marker of Vitamin B12 Deficiency in Alcoholics [PDF]

The Scientific World Journal, 2012
Background. Measurement of serum cobalamin (Cbl) levels is the standard investigation for assessing vitamin B12 deficiency. Falsely increased values of Cbl can be caused by alcoholic liver disease.
Alberto Fragasso, Clara Mannarella, Angela Ciancio, Oronzo Scarciolla, Nicoletta Nuzzolese, Rocco Clemente, Eustachio Vitullo, Andrea Sacco   +7 more
doaj   +5 more sources

The importance of holotranscobalamin measurement [PDF]

Journal of Medical Biochemistry, 2007
Clinically significant vitamin B12 deficiency can occur even with total vitamin B12 levels apparently within normal range. There is an indeterminate zone between approximately 154 and 300 pmol/L of vitamin B12 where there is likely misclassification of ...
Čabarkapa Velibor, Stošić Zoran, Žeravica Radmila, Ilinčić Branislava, Filipović Ana   +4 more
doaj   +2 more sources

Relationship Between the Levels of Holotranscobalamin and Vitamin B12 in Children [PDF]

Indian Journal of Hematology and Blood Transfusion, 2017
The purpose of this study was to evaluate the relationship between the plasma holoTC and serum vitamin B12 in children and to identify a cutoff cobalamin values according to holoTC. One hundred and fifty-five children were enrolled into the study. All children were evaluated for hemoglobin, vitamin B12, folate, ferritin and holoTC levels. Children were
Neşe Yarali, Murat Kizilgun, Ikbal Ok Bozkaya   +2 more
exaly   +5 more sources

Maternal supplementation of vitamin B12 in predominantly vegetarian pregnant women improves their vitamin B12 status and the neurodevelopment of their infants: the MATCOBIND multicentric double-blind randomised control trial [PDF]

BMJ Paediatrics Open
Background Vitamin B12 deficiency is common in populations with limited animal-source foods and has been linked to delayed infant neurodevelopment and adverse pregnancy outcomes.
Michelle Heys, Mario Cortina-Borja, Monica Lakhanpaul, Colin Michie, Jitender Nagpal, Swapnil Rawat, Deepti Nagrath, Atul Singhal, Jageshwor Gautam, Rajendra Pant, Anita Shah, Laura Nixon, Shailendra Bir Karmacharya, Manu Mathur, Vijay Kumar Mishra, Snighda Rai   +15 more
doaj   +2 more sources

Diagnosis and treatment of vitamin B12 deficiency in children [PDF]

Frontiers in Nutrition
Vitamin B12 deficiency is a common yet frequently underrecognized nutritional disorder with important public health implications, particularly in low- and middle-income countries where maternal deficiency, vegetarian dietary practices, and food ...
Purva Kanvinde, Ritika Khurana, Sangeeta Mudaliar   +2 more
doaj   +2 more sources

Failure of the holotranscobalamin assay in vitamin B12-deficient patients [PDF]

Laboratoriums Medizin, 2018
AbstractBackgroundIt has been demonstrated that vitamin B12 determinations fail, especially in patients with pernicious anemia with high titers of intrinsic factor antibody. Consistent with this finding, we observed a case of falsely normal holotranscobalamin (HoloTC) results in a patient with pernicious anemia and severe vitamin B12 deficiency.
Urs E Nydegger, Renz Harald, Lorenz Risch   +2 more
exaly   +2 more sources

Rapid Restoration of Circulating Vitamin B12 Levels by Using Oral Sucrosomial^® Vitamin B12 in Metformin-Associated B12 Deficiency: Results from a Double-Blind, Placebo-Controlled Randomized Clinical Trial [PDF]

Pharmaceutics
Background/Objectives: Vitamin B12 deficiency is common in individuals with type 2 diabetes mellitus (T2DM) receiving long-term metformin therapy, primarily due to impaired intestinal absorption.
Gabriele Conti, Allah W. Kalo, Ikram Ujjan, Aisha Aslam, Amjad Khan, Nazia M. Memon, Shair Z. Kakar, Naseer Ahmed, Shifa Zahid, Germano Tarantino, Elisa Brilli   +10 more
doaj   +2 more sources

Ultra-processed foods and plant-based alternatives impair nutritional quality of omnivorous and plant-forward dietary patterns in college students [PDF]

Scientific Reports
The health benefits of a plant-based diet may be outweighed by an increased consumption of ultra-processed foods (UPF) and plant-based alternatives.
Svenja Fedde, Miriam Wießner, Franziska A Hägele, Manfred J Müller, Anja Bosy-Westphal   +4 more
doaj   +2 more sources

Associations of one-carbon metabolism, related B-vitamins and ApoE genotype with cognitive function in older adults: identification of a novel gene-nutrient interaction [PDF]

BMC Medicine
Background The role of one-carbon metabolism and related B-vitamins in cognitive function in ageing is well-documented, particularly for folate and vitamin B12, with vitamin B6 and riboflavin receiving much less attention.
Shane Gordon, Leane Hoey, Helene McNulty, Jordan Keenan, Faith Pangilinan, Lawrence C. Brody, Mary Ward, J. J. Strain, Liadhan McAnena, Adrian McCann, Anne M. Molloy, Conal Cunningham, Kevin McCarroll, Catherine F. Hughes   +13 more
doaj   +2 more sources

Development and Temporal Validation of Explainable Machine Learning Models for Predicting Vitamin B12 Deficiency Using Routine Laboratory Analytes [PDF]

Diagnostics
Background/Objectives: Vitamin B12 deficiency is a prevalent yet frequently underdiagnosed condition, largely due to the limited diagnostic accuracy of serum total B12 and the restricted availability of confirmatory biomarkers such as holotranscobalamin ...
Ferhat Demirci, Oktay Yıldırım, Aylin Demirci, Pınar Akan   +3 more
doaj   +2 more sources