Haematologica, 2006 Treatment of B12 deficiency is important to prevent progressive neurological and/or hematologic disease but requires a secure diagnosis. The aim of this study was to evaluate second line tests of B12 status as prognostic indicators of a hematologic ...
A Goringe +6 more
doaj +7 more sources
False low holotranscobalamin levels in a patient with a novel TCN2 mutation [PDF]
Clinical Chemistry and Laboratory Medicine (CCLM), 2016 Abstract Background: Measurement of holotranscobalamin (holoTC) is increasingly used as a screening test for cobalamin (Cbl) deficiency. A level well below the reference interval strongly supports a deficient state.
Keller, Peter +5 more
core +6 more sources
Associations of Serum Folate and Holotranscobalamin With Cardiometabolic Risk Factors in Rural and Urban Cameroon [PDF]
Current Developments in Nutrition, 2021 A low intake of fruit and vegetables and a high intake of meat are associated with higher cardiometabolic disease risk; however much prior research has relied on subjective methods for dietary assessment and focused on Western populations. We aimed to investigate the association of blood folate as an objective marker of fruit and vegetable intake and ...
Camille Mba +7 more
core +16 more sources
Characterization of a monoclonal antibody with specificity for holo-transcobalamin [PDF]
Nutrition & Metabolism, 2006 Background Holotranscobalamin, cobalamin-saturated transcobalamin, is the minor fraction of circulating cobalamin (vitamin B12), which is available for cellular uptake and hence is physiologically relevant.
Fedosov Sergey N +7 more
doaj +2 more sources
Assessment of the Vitamin B12 Status of Pregnant Women in Nigeria Using Plasma Holotranscobalamin [PDF]
ISRN Obstetrics and Gynecology, 2011 Maternal vitamin B12 deficiency during pregnancy is an independent risk factor for neural tube defects and other neurological problems in infants. We determined the vitamin B12 status of 143 pregnant women in Nigeria representing all trimesters who presented to an antenatal clinic in Jos, Nigeria, using holotranscobalamin II levels (holoTCII), which is
VanderJagt, Dorothy J. +7 more
openaire +4 more sources
Associations between serum homocysteine, holotranscobalamin, folate and cognition in the elderly: a longitudinal study [PDF]
Journal of Internal Medicine, 2011 Abstract. Hooshmand B, Solomon A, Kåreholt I, Rusanen M, Hänninen T, Leiviskä J, Winblad B, Laatikainen T, Soininen H & Kivipelto M (Aging Research Center, Karolinska Institutet, Stockholm, Sweden; KI Alzheimer’s Disease Research Center (KI‐ADRC), Karolinska Institutet, Stockholm, Sweden; National Institute for Health and Welfare (THL), Helsinki ...
B, Hooshmand +9 more
openaire +3 more sources
B vitamins and cardiovascular health: mechanisms, clinical evidence, and precision prevention strategies [PDF]
Nutrition & MetabolismBackground Cardiovascular diseases is the most common cause of mortality in the world. B vitamins (B₁–B₁₂) control how mitochondria make energy, how nitric oxide is made, how one-carbon is used, and how genes work.
Ameer Awashra +11 more
doaj +2 more sources
Vitamin B12 deficiency in an infant secondary to nutritional deficiency and an inadequate maternal diet. [PDF]
JPGN RepABSTRACT Vitamin B12 (cobalamin, Cbl) is an essential micronutrient for DNA synthesis and neurological development. Its deficiency in infants, although infrequent in developed countries, can cause megaloblastic anemia, psychomotor delay, and neurological damage that may become irreversible if not treated early.
Sala-Lluch S +5 more
europepmc +2 more sources
Holotranscobalamin and methylmalonic acid as the diagnostic tool for vitamin B12 deficiency
Indian Journal of Dermatology, 2015 Kanica Kaushal
doaj +3 more sources