Results 11 to 20 of about 494 (158)

Holotranscobalamin Is a Useful Marker of Vitamin B12 Deficiency in Alcoholics [PDF]

The Scientific World Journal, 2012
Background. Measurement of serum cobalamin (Cbl) levels is the standard investigation for assessing vitamin B12 deficiency. Falsely increased values of Cbl can be caused by alcoholic liver disease.
Alberto Fragasso, Clara Mannarella, Angela Ciancio, Oronzo Scarciolla, Nicoletta Nuzzolese, Rocco Clemente, Eustachio Vitullo, Andrea Sacco   +7 more
doaj   +5 more sources

False low holotranscobalamin levels in a patient with a novel TCN2 mutation. [PDF]

Clinical Chemistry and Laboratory Medicine (CCLM), 2016
BACKGROUND Measurement of holotranscobalamin (holoTC) is increasingly used as a screening test for cobalamin (Cbl) deficiency. A level well below the reference interval strongly supports a deficient state.
Rufener, Janine, Nexo, Ebba, Nissen, Peter H, Fedosov, Sergey N, Keller, Peter, Schild, Christof   +5 more
core   +5 more sources

The limited value of methylmalonic acid, homocysteine and holotranscobalamin in the diagnosis of early B12 deficiency

Haematologica, 2006
Treatment of B12 deficiency is important to prevent progressive neurological and/or hematologic disease but requires a secure diagnosis. The aim of this study was to evaluate second line tests of B12 status as prognostic indicators of a hematologic ...
A Goringe, R Ellis, I McDowell, J Vidal-Alaball, C Jenkins, C Butler, M Worwood   +6 more
doaj   +5 more sources

Assessment of the Vitamin B12 Status of Pregnant Women in Nigeria Using Plasma Holotranscobalamin [PDF]

ISRN Obstetrics and Gynecology, 2011
Maternal vitamin B12 deficiency during pregnancy is an independent risk factor for neural tube defects and other neurological problems in infants. We determined the vitamin B12 status of 143 pregnant women in Nigeria representing all trimesters who ...
Innocent A. O. Ujah, Michael J. Crossey, Robert H. Glew, Jessica Bryant, Victor Pam, Eugene I. Ikeh, Amelia Hilgart, Dorothy J. VanderJagt   +7 more
core   +4 more sources

Associations of Serum Folate and Holotranscobalamin With Cardiometabolic Risk Factors in Rural and Urban Cameroon [PDF]

Current Developments in Nutrition, 2021
A low intake of fruit and vegetables and a high intake of meat are associated with higher cardiometabolic disease risk; however much prior research has relied on subjective methods for dietary assessment and focused on Western populations.
Albert Koulman, Nita G. Forouhi, Nick J. Wareham, Nicholas Wareham, Camille M. Mba, Jean Claude Mbanya, Nita Forouhi, Felix Assah, Stephen Sharp, Fumiaki Imamura, Camille Mba   +10 more
core   +8 more sources

Associations between serum homocysteine, holotranscobalamin, folate and cognition in the elderly: a longitudinal study [PDF]

Journal of Internal Medicine, 2011
Objectives:  To examine the associations of serum homocysteine (tHcy), Holotranscobalamin (holoTC), the biologically active fraction of vitamin B12, and folate with cognitive functioning in a longitudinal population-based study of Finnish elderly ...
Hooshmand, Babak,, Kareholt, I., Soininen, H., Winblad, Bengt, Solomon, Alina, Laatikainen, Tiina, Laatikainen, T., T. Hänninen, A. Solomon, M. Rusanen, Hooshmand, B,, Hooshmand, B., I. Kåreholt, Soininen, Hilkka, M. Kivipelto, Kareholt, I, Kivipelto, M,, B. Hooshmand, Kivipelto, Miia,, Kivipelto, M., J. Leiviskä, Leiviskä, Jaana, Laatikainen, T, Winblad, B., Rusanen, Minna, Leiviska, J, Kåreholt, Ingemar,, Winblad, B,, Hanninen, T., Hanninen, T, Rusanen, M., Leiviska, J., B. Winblad, Hänninen, Tuomo, Soininen, H, Rusanen, M, Solomon, A., T. Laatikainen, H. Soininen, Solomon, A,, Kivipelto, Miia, Hooshmand, Babak   +41 more
core   +3 more sources

Homocysteine and holotranscobalamin and the risk of Alzheimer disease: A longitudinal study

Neurology, 2010
OBJECTIVE: To examine the relation between serum levels of homocysteine (tHcy) and holotranscobalamin (holoTC), the active fraction of vitamin B12, and risk of incident Alzheimer disease (AD) in a sample of Finnish community-dwelling elderly.
S. Ahtiluoto, Hooshmand, Babak,, I. Kareholt, A. Solomon, M. Rusanen, Hooshmand, B,, Solomon, A, Leiviskä, J, M. Kivipelto, Kareholt, I, Kivipelto, M,, B. Hooshmand, Kivipelto, Miia,, Laatikainen, T, J. Leiviska, Kåreholt, Ingemar,, Winblad, B,, Ahtiluoto, S, B. Winblad, Soininen, H, Rusanen, M, T. Laatikainen, H. Soininen, Winblad, B, Solomon, A,   +24 more
core   +3 more sources

Holotranscobalamin and methylmalonic acid as the diagnostic tool for vitamin B12 deficiency

Indian Journal of Dermatology, 2015
Kanica Kaushal
doaj   +3 more sources

Age dependency of plasma vitamin B12 status markers in Dutch children and adolescents [PDF]

, 2021
Background Vitamin B12 deficiency in children may be associated with (severe) neurological manifestations, therefore recognition is important. Diagnosing vitamin B12 deficiency in children is challenging.
van Zanden, Jelmer J., Wiersema, Nicole S., Kootstra-Ros, Jenny E., Pinxterhuis, Tineke H., de Jong, Wilhelmina H. A., Heiner-Fokkema, M. Rebecca; id_orcid, Hooimeijer, H. Louise, van Spronsen, Francjan J., Kobold, Anneke C. Muller; id_orcid, Riphagen, Ineke J., Francjan J. van Spronsen, Jelmer J. van Zanden, Tineke H. Pinxterhuis, Ineke J. Riphagen, Jenny E. Kootstra-Ros, Wilhelmina H. A. de Jong, Nicole S. Wiersema, Anneke C. Muller Kobold, M. Rebecca Heiner-Fokkema, H. Louise Hooimeijer   +19 more
core   +1 more source

Holotranscobalamin as an Indicator of Dietary Vitamin B12 Deficiency [PDF]

Clinical Chemistry, 2003
We report that serum holotranscobalamin (holoTC) compares favorably with serum vitamin B12 for identifying vegans likely to have vitamin B12 deficiency as judged by measurements of the metabolites methylmalonic acid (MMA) and homocysteine (tHcy). We also report that measurement of holoTC may possibly replace combined testing with serum vitamin B12 (B12)
Lloyd-Wright, Z, Hvas, A M, Moller, J, Sanders, T A B, Nexo, E   +4 more
openaire   +5 more sources