Results 41 to 50 of about 1,234 (191)

Vitamin B12 Status in Recreational Users of Nitrous Oxide: A Systematic Review Focusing on the Prevalence of Laboratory Abnormalities

Antioxidants, 2023
The recreational use of nitrous oxide (N2O) as “laughing gas” is a growing problem. The chronic toxicity of N2O is mainly due to its ability to oxidize vitamin B12, making it dysfunctional as a cofactor in metabolic pathways. This mechanism plays a major
Tanguy Ménétrier, Damien Denimal
doaj   +1 more source

Elevated Homocysteine after Elevated Propionylcarnitine or Low Methionine in Newborn Screening Is Highly Predictive for Low Vitamin B12 and Holo-Transcobalamin Levels in Newborns

Diagnostics, 2020
Early diagnostics and treatment of vitamin B12 deficiency (B12D) in infants, mainly maternally conditioned, is crucial in preventing possible developmental delay and neurological deficits.
Tomaž Rozmarič, Goran Mitulović, Vassiliki Konstantopoulou, Bernadette Goeschl, Martina Huemer, Barbara Plecko, Johannes Spenger, Saskia B. Wortmann, Sabine Scholl-Bürgi, Daniela Karall, Susanne Greber-Platzer, Maximilian Zeyda   +11 more
doaj   +1 more source

Serum Total Vitamin B12 or Active Vitamin B12: Which is a Better Marker for Vitamin B12 Deficiency during Pregnancy? A Retrospective Cohort Study from South India

Current Medical Issues
Background: Serum Vitamin B12 level is routinely analyzed using total Vitamin B12 assay. It can also be analyzed by active B12 assay. In this study, we compared the association of total and active Vitamin B12 levels with maternal medical complications ...
Rosa Mariam Mathew, G. Jayakumar Amirtharaj, N. D. Varunashree, Maya Pavalasseril Ganeshan, Anuja Abraham, Swati Rathore, Pamela Christudoss, Gowri Mahasampath, Dheeraj Kattula   +8 more
doaj   +1 more source

Holotranscobalamin: Not Ready for Prime Time

Clinical Chemistry, 2012
To the Editor: In their recent article in Clinical Chemistry (1), Valente and colleagues advocate that holotranscobalamin II (holoTC)1 become the primary diagnostic test of vitamin B12 status. I believe that study flaws undercut the authors' recommendation.
openaire   +2 more sources

Low vitamin B-12 status in confirmed Alzheimer's disease as revealed by serum holotranscobalamin.

, 2003
OBJECTIVE: To examine the possible association of holotranscobalamin, the active fraction of serum cobalamin, with Alzheimer's disease. METHODS: 51 patients with pathologically confirmed Alzheimer's disease and 65 cognitively screened elderly controls ...
Refsum, H, Smith, AD
core   +1 more source

Clinical utility of serum holotranscobalamin in the assessment of Vitamin B12 deficiency in patients with Hypothyroidism [PDF]

, 2021
Thyroid disorder is the second most frequently encountered endocrinological condition after diabetes mellitus. When vitamin B12 deficiency coexists with hypothyroidism, neurological symptoms and signs are more pronounced.
Kumar, Kiran, DSa, Janice, Nair, Vishnu, Shridhar, Reshma, Sushith, Nair, Suriyan, Mangalore Balakrishna, Prathima   +6 more
core  

Serum Holotranscobalamin and Methylmalonic Acid as Early Markers of Vitamin B12 Deficiency in Pregnant Females

Indian Journal of Medical Specialities
Background: Screening for Vitamin B12 deficiency in pregnancy is not routinely done in antenatal care. Serum Vitamin B12 assay has low sensitivity and specificity; therefore, this study was conducted to assess the usefulness of holotranscobalamin (HoloTC)
Fallguni Arora, Sunita Sharma, Kiran Aggarwal   +2 more
doaj   +1 more source

Cross-sectional association between vitamin B12 status and probable postpartum depression in Indian women

BMC Pregnancy and Childbirth, 2021
Background Vitamin B12 is an essential micronutrient for neurological function, as it leads to the regeneration of methionine from homocysteine, which is precursor of biologically active molecule S-Adenosyl Methionine (SAM).
Pooja Dhiman, Raji Ramachandran Pillai, Anand Babu Wilson, Nancy Premkumar, Balaji Bharadwaj, Veena P. Ranjan, Soundravally Rajendiran   +6 more
doaj   +1 more source

Serum Transcobalamin Concentration in Cats—Method Validation and Evaluation in Chronic Enteropathies and Other Conditions

Veterinary Sciences
Hypocobalaminemia is common in cats with chronic enteropathy (FCE). However, the disruptions in cobalamin metabolism are not fully understood and may vary across species.
Tim Kunath, Stefanie Kather, Franziska Dengler, Ebba Nexo, Helga Pfannkuche, Romy M. Heilmann   +5 more
doaj   +1 more source

Holotranscobalamin and methylmalonic acid as prognostic markers following an acute myocardial infarction [PDF]

European Journal of Clinical Nutrition, 2007
To evaluate whether low levels of holotranscobalamin (holoTC) or elevated levels of methylmalonic acid (MMA), both indicators of vitamin B(12) deficiency, might predispose to new cardiovascular events following an acute myocardial infarction (MI).A prospective prognostic study.One hospital center in Stavanger, Norway.A total of 300 patients admitted ...
H, Aarsetøy, E, Valente, A, Reine, M A, Mansoor, H, Grundt, D W T, Nilsen   +5 more
openaire   +2 more sources