Results 31 to 40 of about 494 (158)

The role of holotranscobalamin in examination of vitamin B12 status

Medicinski pregled, 2008
Introduction. Holotranscobalamin contains biologically available cobalamin because only holotranscobalamin promotes the uptake of the cobalamin therein by all cells, via specific receptors. Therefore holotranscobalamin has been proposed as a potentially useful alternative indicator of vitamin B12 status.
Velibor, Cabarkapa, Zoran, Stosić, Vera, Uzurov, Vladimir, Sakac, Mirjana, Derić   +4 more
openaire   +3 more sources

Measurement of holotranscobalamin in assessing vitamin B12 status [PDF]

, 2016
Cilj istraživanja bio je ispitati je li holotranskobalamin osjetljiviji pokazatelj deficita vitamina B12 u odnosu na kobalamin, te postoji li povezanost između kobalamina i holotranskobalamina s homocisteinom.
Vuk, Darko
core   +1 more source

Pre-conceptional Maternal Vitamin B12 Supplementation Improves Offspring Neurodevelopment at 2 Years of Age: PRIYA Trial

Frontiers in Pediatrics, 2021
Background: The first thousand days window does not include the pre-conceptional period. Maternal pre-conceptional health has a profound influence on early embryonic development (implantation, gastrulation, placentation etc).
Naomi D'souza, Rishikesh V. Behere, Bindu Patni, Madhavi Deshpande, Dattatray Bhat, Aboli Bhalerao, Swapnali Sonawane, Rohan Shah, Rasika Ladkat, Pallavi Yajnik, Souvik K. Bandyopadhyay, Kalyanaraman Kumaran, Caroline Fall, Chittaranjan S. Yajnik   +13 more
doaj   +1 more source

Low vitamin B-12 status in confirmed Alzheimer's disease as revealed by serum holotranscobalamin.

, 2003
OBJECTIVE: To examine the possible association of holotranscobalamin, the active fraction of serum cobalamin, with Alzheimer's disease. METHODS: 51 patients with pathologically confirmed Alzheimer's disease and 65 cognitively screened elderly controls ...
H Refsum
core   +1 more source

Elevated Homocysteine after Elevated Propionylcarnitine or Low Methionine in Newborn Screening Is Highly Predictive for Low Vitamin B12 and Holo-Transcobalamin Levels in Newborns

Diagnostics, 2020
Early diagnostics and treatment of vitamin B12 deficiency (B12D) in infants, mainly maternally conditioned, is crucial in preventing possible developmental delay and neurological deficits.
Tomaž Rozmarič, Goran Mitulović, Vassiliki Konstantopoulou, Bernadette Goeschl, Martina Huemer, Barbara Plecko, Johannes Spenger, Saskia B. Wortmann, Sabine Scholl-Bürgi, Daniela Karall, Susanne Greber-Platzer, Maximilian Zeyda   +11 more
doaj   +1 more source

Vitamin B12 Status in Recreational Users of Nitrous Oxide: A Systematic Review Focusing on the Prevalence of Laboratory Abnormalities

Antioxidants, 2023
The recreational use of nitrous oxide (N2O) as “laughing gas” is a growing problem. The chronic toxicity of N2O is mainly due to its ability to oxidize vitamin B12, making it dysfunctional as a cofactor in metabolic pathways. This mechanism plays a major
Tanguy Ménétrier, Damien Denimal
doaj   +1 more source

Holotranscobalamin: Not Ready for Prime Time

Clinical Chemistry, 2012
To the Editor: In their recent article in Clinical Chemistry (1), Valente and colleagues advocate that holotranscobalamin II (holoTC)1 become the primary diagnostic test of vitamin B12 status. I believe that study flaws undercut the authors' recommendation.
openaire   +2 more sources

Holotranscobalamin is not influenced by decreased renal function in elderly men: the MrOS Sweden study

, 2013
Background Subclinical cobalamin deficiency is common in the elderly, but the sensitivity and specificity of serum total cobalamin for this diagnosis is poor. Serum holotranscobalamin (holoTC), a measure of biologically available cobalamin, is considered
Jacobsson, Stefan, Ohlsson, Claes, Mellstrom, Dan, Lewerin, Catharina, Nilsson-Ehle, Herman, Ohlsson, Claes,, Lewerin, Catharina,, Mellström, Dan,, Karlsson, Magnus,, Karlsson, Magnus K, Jacobsson, Stefan,, Lund University., Nilsson-Ehle, Herman,   +12 more
core   +2 more sources

Serum Holotranscobalamin and Methylmalonic Acid as Early Markers of Vitamin B12 Deficiency in Pregnant Females

Indian Journal of Medical Specialities
Background: Screening for Vitamin B12 deficiency in pregnancy is not routinely done in antenatal care. Serum Vitamin B12 assay has low sensitivity and specificity; therefore, this study was conducted to assess the usefulness of holotranscobalamin (HoloTC)
Fallguni Arora, Sunita Sharma, Kiran Aggarwal   +2 more
doaj   +1 more source

Serum Total Vitamin B12 or Active Vitamin B12: Which is a Better Marker for Vitamin B12 Deficiency during Pregnancy? A Retrospective Cohort Study from South India

Current Medical Issues
Background: Serum Vitamin B12 level is routinely analyzed using total Vitamin B12 assay. It can also be analyzed by active B12 assay. In this study, we compared the association of total and active Vitamin B12 levels with maternal medical complications ...
Rosa Mariam Mathew, G. Jayakumar Amirtharaj, N. D. Varunashree, Maya Pavalasseril Ganeshan, Anuja Abraham, Swati Rathore, Pamela Christudoss, Gowri Mahasampath, Dheeraj Kattula   +8 more
doaj   +1 more source