Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids
Advanced Science, EarlyView.Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang +6 more
wiley +1 more source
Advanced Science, EarlyView.The S100A4/STAT3 axis promotes Rmrp transcription in AEC‐IIs and Rmrp expression in AEC‐II‐derived exosomes. Upon entry into AMs, Rmrp binds to and blocks the ubiquitination and degradation of ZFP36. Increased ZFP36 induced Pfkfb3 mRNA decay by binding to AREs in the 3′ UTR, curbing glycolysis and immune responses of AMs and aggravating SII and ...
Chengxi Liu +17 more
wiley +1 more source
Optic neuropathy as a presenting feature of vitamin B-12 deficiency: A systematic review of literature and a case report. [PDF]
Ann Med Surg (Lond), 2020 Ata F +7 more
europepmc +1 more source
The Pathogenesis of Megaloblastic Anaemias and the Value of Vitamin B12 [PDF]
, 1952 C. C. Ungley
openalex +1 more source
Vitamin B-12, Homocysteine, and Hematological Parameters in Ischemic Stroke Patients
, 2023 Jane Betsy Isaac, Vijayashree Raghavan
openalex +1 more source
The Pathogenic Roles of Local Vitamin D Metabolism Defect in Valve Inflammation and Calcification
Advanced Science, EarlyView.This study identifies the valvular interstitial cell populations responsible for valvular calcification induced by hyperphosphatemia and likely aging, uncovers local vitamin D metabolism defect‐induced inflammation as a critical pathogenic factor of calcific aortic valve disease, and highlights active vitamin D and ERK inhibitor as potential preventive
Ruichen Yang +10 more
wiley +1 more source
Folate and Vitamin B-12 Status Is Associated With Bone Mineral Density and Hip Strength of Postmenopausal Chinese-Singaporean Women. [PDF]
JBMR Plus, 2020 Kalimeri M +8 more
europepmc +1 more source
Studies on Vitamin B<SUB>12</SUB>. I. : Thiamine as a Degradafion Factor of Cobalamins
, 1969 Kiyoshi Harada +4 more
openalex +2 more sources
Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis
Advanced Science, EarlyView.Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang +16 more
wiley +1 more source
A 50-year-old female with dysuria, dysporia, numbness and weakness of extremities
Chinese Journal of Contemporary Neurology and Neurosurgery, 2015 This paper reports one patient, with a history of autoimmune gastritis, who presented dysuria and dysporia for 5 years, weakness of left upper limb for one and a half years, and numbness and weakness of extremities for 2 months.
Lin PENG +3 more
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