Results 251 to 260 of about 900,461 (349)

Targeting the Notch1‐YY1‐ICAM1 Signaling Axis Enhances the Efficacy of Immunotherapy in HCC by Activating CD8+ T‐Cell‐Driven Cancer Cell Pyroptosis

open access: yesAdvanced Science, EarlyView.
In hepatocellular carcinoma (HCC), aberrantly activated Notch1 signaling induces its target gene YY1, which impairs immunotherapy efficacy by suppressing tumor cell‐ICAM1‐driven T cell activation and the mediated pyroptosis of T cells against tumor cells.
Ke Zhu   +10 more
wiley   +1 more source

Immunomodulatory Hydrogel Coating with SeNPs and Lithium Silicate Synergistically Promotes Osseointegration and Prevents Infection on Titanium Implants

open access: yesAdvanced Science, EarlyView.
This study introduces a multifunctional hydrogel coating (Lap‐CMCSMA/GelMA@SeNPs) that scavenges ROS, modulates immune responses, and shows strong antibacterial activity. It effectively restores the peri‐implant microenvironment. The coating exhibits excellent biocompatibility and promotes osteogenic differentiation.
Su Jiang   +7 more
wiley   +1 more source

DNA Origami and Its Applications in Synthetic Biology

open access: yesAdvanced Science, EarlyView.
This review provides a comprehensive summary of recent advancements in DNA origami for synthetic biology, emphasizing two key areas: the precise construction and dynamic regulation of extracellular‐to‐intracellular, and the synergistic integration with cell‐free systems.
Yaning Fang   +4 more
wiley   +1 more source

Fever Inspiration: Precision Engineering for Safe and Systemic Immunotherapy

open access: yesAdvanced Science, EarlyView.
This review examines engineered fever therapy (EFT) as a novel cancer treatment, harnessing fever's immunomodulatory effects to enhance systemic immune responses. It explores molecular mechanisms, advances in nanotechnology‐driven thermal immunotherapy, and a bioengineered framework for precise, safe fever induction. The paper evaluates EFT's potential
Yang Li   +5 more
wiley   +1 more source

Effectiveness of Multivitamins vs Folic Acid on Prevention of Neural Tube Defects in Mouse Genetic Models and Human Organoids

open access: yesAdvanced Science, EarlyView.
Folic acid (FA) and multivitamins/minerals (MVM) are recommended for the prevention of neural tube defects (NTDs). Using a novel human neural tube‐like organoid system and mouse models, the study compares the effectiveness of two supplements on NTDs and cellular behaviors.
Huili Li   +3 more
wiley   +1 more source

Hot‐Pressing Annealing‐Induced Light Utilization Enhancement and Crystallinity Optimization Enable High‐Performance Narrowband Ultraviolet Photodetectors for Real‐Time Ultraviolet Radiation Monitors

open access: yesAdvanced Science, EarlyView.
By utilizing a hot‐pressing (HP) annealing strategy, Cs3Cu2I5 films with larger grains vertically spanning the entire thickness are fabricated. Because HP annealing enhances light utilization and charge transport in Cs3Cu2I5/GaN heterojunction, the HP device achieves superior detection performance while maintaining narrowband photoresponse to UVA/UVB ...
Jingli Ma   +13 more
wiley   +1 more source

The Relationship of Vitamin B 12 with Two Difficult Complications of Shingles: Who has Pain and Who has Itch?

open access: diamond
İlkay ÖZER   +4 more
openalex   +1 more source

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