Results 271 to 280 of about 886,264 (353)

Centimeter‐Scale Self‐Assembling Tendon Organoids Drive Tissue Regeneration

Advanced Science, EarlyView.
Centimeter‐scale tendon organoids are engineered by mimicking the extracellular matrix and optimizing chemical cues to guide tendon stem/progenitor cells. These large, self‐assembling constructs overcome conventional size limitations and exhibit enhanced tenogenic differentiation, extracellular matrix production, and mechanical resilience. Their tissue‐
Tianshun Fang, Hong Zhang, Yuanhao Xie, Xiongfeng Li, Xi Liu, Zichen Wang, Yiwen Xue, Xiaohui Xia, Zetao Wang, Tingyun Lei, Ruifu Lin, Weiliang Shen, Bingbing Wu, Yishan Chen, Yanan Du, Xiao Chen, Zi Yin   +16 more
wiley   +1 more source

Suppressing Glycerol‐3‐phosphate Phosphatase and Enhancing Glycerol‐3‐Phosphate Shuttle Flux Crucial for High‐Efficiency Fatty Acid Production in the Fast‐Growing Oleaginous Schizochytrium

Advanced Science, EarlyView.
This study establishes an efficient oleaginous heterotrophic microalga, Schizochytrium, through chassis optimization and metabolic engineering, significantly enhancing fatty acid titers and productivities. It also identifies a regulatory mechanism that coordinates biomass and lipid synthesis, providing a rational target for metabolic pathway rewiring ...
Fangzhong Wang, Weijia Jin, Tiantian Wang, Junkai Ji, Kun Cao, Jianqiang Li, Lei Chen, Weiwen Zhang   +7 more
wiley   +1 more source

Proton Pump Inhibitors, H2-Receptor Antagonists, Metformin, and Vitamin B-12 Deficiency: Clinical Implications. [PDF]

Adv Nutr, 2018
Miller JW.
europepmc   +1 more source

A Correlation Between Nuclear Diameters of Oral Epithelial Squamous Cells and Blood Vitamin B₁₂ Levels of Children with Nutritional Dystrophy

, 1960
Hiromichi Oyake, Zenichiro Kudo, Tsuneo Arakawa   +2 more
openalex   +2 more sources

Retromer Regulates Macro‐ and Micro‐Autophagy via Distinct Vacuolar Proteases in the Rice Blast Fungus

Advanced Science, EarlyView.
In wild‐type of M. oryzae (Guy11), MoPrb1 and MoPep4 are delivered into the vacuole by the retromer complex to mediate protein degradation and selective autophagy. Their proper localization and catalytic functions are essential for the fungal vegetative growth, conidiation and pathogenicity. However, retromer mutations disrupt this transport, impairing
Dingyang Zhang, Jiexiong Hu, Yonghe Hong, Yuping Fan, Minghui Peng, Yakubu Saddeeq Abubakar, Shujing Liang, Nan Jiang, Lili Lin, Xiaohong Pan, Huakun Zheng, Naweed I. Naqvi, Zonghua Wang, Wenhui Zheng   +13 more
wiley   +1 more source

SP1‐Mediated Glycolytic Reprogramming Promotes Tumorigenesis and Progression in Pancreatic Cancer

Advanced Science, EarlyView.
Laser capture microdissection‐based proteomics of pancreatic intraepithelial neoplasia (PanIN) identifies specificity protein 1 (SP1) as a key driver of tumorigenesis and progression in pancreatic cancer through glycolytic remodeling. SP1 enhances aerobic glycolysis by transcriptionally activating 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase ...
Hexing Hang, Mengyu Yu, Linxi Zhu, Neng Tang, Xiao Fu, Zhenghua Cai, Minghao Yan, Yi Chen, Lei Yang, Jianzhuang Wu, Jiatong Tang, Yu Xie, Qi Li, Xu Fu, Liang Mao, Jun Chen, Fanqing Meng, Bo Kong, Xiaodong Han, Chao Yan, Yudong Qiu, Hao Cheng   +21 more
wiley   +1 more source

Book Review: Studies in the Metabolism of Vitamin B₁₂

, 1965
Sheila T. Callender
openalex   +1 more source

Steric‐Adaptive Biocatalysis: Imine Reductase‐Mediated Dynamic Kinetic Resolution for Atroposelective Synthesis of Hindered Biaryl Amines

Advanced Science, EarlyView.
An unusual IRED platform is reported, enabling efficient DKR via reductive amination without any evolutionary engineering. The system accommodates extremely sterically demanding substrates, including naphthyl and quinoline derivatives, delivering naphthyl‐aryl and quinoline‐aryl amine atropisomers with excellent efficiency and stereocontrol (over 80 ...
Zhichao Ni, Jingyuan Zhuang, Yadong Gao, Guangsheng Gao, Zhenling Liu, Ping Su, Gui‐Juan Cheng, Li‐Cheng Yang   +7 more
wiley   +1 more source

A physiological dose of oral vitamin B-12 improves hematological, biochemical-metabolic indices and peripheral nerve function in B-12 deficient Indian adolescent women. [PDF]

PLoS One, 2019
Yajnik CS, Behere RV, Bhat DS, Memane N, Raut D, Ladkat R, Yajnik PC, Kumaran K, Fall CHD.   +8 more
europepmc   +1 more source