Results 61 to 70 of about 886,264 (353)

Cellular Import of Cobalamin (Vitamin B-12) [PDF]

The Journal of Nutrition, 1999
Recent studies have isolated and characterized human gastric intrinsic factor (IF) and transcobalamin II (TC II) genes, whose products mediate the import of cobalamin (Cbl; Vitamin B-12) across cellular plasma membranes. Analyses of cDNA and genomic clones of IF and TC II have provided some important insights into their sites of expression, structure ...
Bellur Seetharam, Ning Li, Santanu Bose
openaire   +3 more sources

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

14C-Cobalamin Absorption from Endogenously Labeled Chicken Eggs Assessed in Humans Using Accelerator Mass Spectrometry. [PDF]

, 2019
Traditionally, the bioavailability of vitamin B-12 (B12) from in vivo labeled foods was determined by labeling the vitamin with radiocobalt (57Co, 58Co or 60Co).
Allen, Lindsay H, Buchholz, Bruce A, Calvert, Christopher C, Garrod, Marjorie G, Green, Ralph, Miller, Joshua W, Rossow, Heidi A   +6 more
core   +2 more sources

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Assessment of biochemical factors in blood serum of patients with oral squamous cell carcinoma

Dental Research Journal, 2023
Background: Recently, the role of biochemical factors in the etiology of oral squamous cell carcinoma (OSCC) has attracted some attention. Serum levels of biochemical factors may change in cancer patients.
Forooz Keshani, Alireza Mahmoodi, Masood Gholami, Faezeh Azmoudeh   +3 more
doaj   +1 more source

Holo-transcobalamin is an indicator of vitamin B-12 absorption in healthy adults with adequate vitamin B-12 status [PDF]

The American Journal of Clinical Nutrition, 2007
It has been hypothesized that the response of holo-transcobalamin (holo-TC) to oral vitamin B-12 may be used to assess absorption. To develop a reliable clinical absorption test that uses holo-TC, it is necessary to determine the optimal timeline for vitamin B-12 administration and postdose assessment.The objective of this study was to assess the ...
Gail P. A. Kauwell, Claire A Edgemon, Ebba Nexø, Jonathan J. Shuster, David R. Maneval, Lynn B. Bailey, John F. Valentine, Anne Louise Morkbak, Kristina M von Castel-Roberts   +8 more
openaire   +3 more sources

A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications

Molecular Oncology, EarlyView.
Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).
Lina Hacker, Elysia Sarsam, Stuart J. Conway, Ester M. Hammond   +3 more
wiley   +1 more source

Quantification of vitamin B₁₂ in infant formula by dimensional liquid chromatography with solid phase extraction

浙江大学学报. 农业与生命科学版, 2013
Only a small amount of vitamin B12 is absorbed and utilized by human body. The suitable vitamin B12 levels can improve the utilization efficiency of folic acid. Excessive intake of vitamin B12 may cause allergic reactions, while vitamin B12 deficiency in
CHU Xiaojun, TAO Baohua, LAI Shiyun, ZHANG jingshun, SONG Yiwen, REN Yiping   +5 more
doaj   +1 more source

Evolution of plasma vitamin B 12 in patients with solid cancers during curative versus supportive care

Archives of Medical Science, 2021
Introduction The direction of the causal link between solid cancers and elevated plasma vitamin B 12 (B 12 ) remains uncertain. Material and methods We retrospectively included patients having two B 12 measurements with a B 12 initially ≥ 1000 ng/l ...
Valentin Lacombe, Anne Patsouris, Estelle Delattre, Carole Lacout, Geoffrey Urbanski   +4 more
doaj   +1 more source

Vitamin B-12 supplementation improves arterial function in vegetarians with subnormal vitamin B-12 status

The Journal of nutrition, health and aging, 2012
Vegetarians are more vascular-healthy but those with subnormal vitamin B-12 status have impaired arterial endothelial function and increased intima-media thickness. We aimed to study the impact of vitamin B-12 supplementation on these markers, in the vegetarians.Double-blind, placebo controlled, randomised crossover study.Community dwelling vegetarians.
Y. K. P. Poon, Lai-Shan Tam, Jean Woo, Anil T. Ahuja, David S. Celermajer, Mu Qiao, Ping Chook, Timothy Kwok, Kam S. Woo   +8 more
openaire   +3 more sources