Results 121 to 130 of about 19,034,701 (255)

Multi‐regional Organoid Biobank Reveals FAK‐ACSL1‐Driven Doxorubicin‐Resistance and Predictive Biomarkers in Breast Cancer

Advanced Science, EarlyView.
This study established a high‐quality organoid biobank derived from 68 tumor sites across 50 Chinese patients, elucidated the drug sensitivity‐based molecular subtyping in breast cancer, and revealed a novel mechanism of drug resistance mediated by the FAK‐ACSL1 pathway.
Hao Xu, Zhijun Qin, Jiapeng Yang, Baoyuan Zhang, Manqing Cao, Peng Wang, Zaiqi Wang, Jinghui Cheng, Lei Wang, Hong Liu, Hui Yang   +10 more
wiley   +1 more source

Paraoxonase and Arylesterase Activities in Children With Iron Deficiency Anemia and Vitamin B-12 Deficiency Anemia

, 2012
Paraoxonase-1 is an esterase enzyme and it has 3 types of activity, namely paraoxonase, arylesterase, and diazoxonase. It has been reported that paraoxonase-1 deficiency is related to increased susceptibility to development of atherosclerosis and ...
Ozdemir, ZEYNEP CANAN, Celik, Hakim, Koc, Ahmet, Cengiz, Murad   +3 more
core   +1 more source

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

Vitamin B-12 deficiency after esophagectomy with gastric tube reconstruction for esophageal cancer

, 2017
The aim of this study is to determine the prevalence and incidence of vitamin B12 deficiency after esophagectomy for cancer. It is unknown if patients after esophagectomy with gastric tube reconstruction are at an increased risk for vitamin B-12 ...
van Lanschot, J. J. B., van der Stok, E. P., J J B van Lanschot, Lindemans, J, Lindemans, J., Wijnhoven, B. P.L., Wijnhoven, B. P. L., B P L Wijnhoven, Hötte, Gijsbert, van Lanschot, Jan, Hotte, G. J., de Jonge, R, P van Hagen, M I van Berge Henegouwen, E P van der Stok, van der Stok, EP, van Berge Henegouwen, M. I., Henegouwen, MIV, van Hagen, P.M., de Jonge, R., van Lanschot, J. J.B., R de Jonge, G J Hötte, van Hagen, P., Wijnhoven, Bas, J Lindemans   +25 more
core   +1 more source

Vitamin B12 deficiency and its impact on healthcare: a population-level analysis and call for action

Frontiers in Nutrition
IntroductionVitamin B12 deficiency is a growing health concern, affecting millions worldwide. This study aims to evaluate the pattern of vitamin B12 deficiency in a large healthcare system and assess its impact on hospitalizations and associated diseases.
Leonardo P. de Carvalho, Leonardo P. de Carvalho, Nelson Akamine, Nelson Akamine, Marcelo S. Di Pietro, Marcelo S. Di Pietro, Carolina Nunes França, Rodrigo Oliveira, Renato D. Lopes, Renato D. Lopes, Renato D. Lopes   +10 more
doaj   +1 more source

Super‐Multiplexed Label‐Free Raman Imaging Uncovers Novel Testicular Metabolic Couplings for Residual Body and Spermatogonial Differentiation

Advanced Science, EarlyView.
Super‐multiplexed Label‐free Raman Imaging (SLRI) enables 2D/3D metabolic mapping of intact Drosophila testes. Moving beyond descriptive morphology, it establishes a multidimensional tool for tissue metabolic remodeling, and offers a generalizable platform for complex tissue analysis, with implications extending to development and disease. ABSTRACT The
Jiaxin Li, Xia Chen, Yujuan Qi, Chen Qiao, Qiuru Huang, Dan Zhao, Weiyi Qian, Li Di, Yi Shi, Xiangqi Hu, Yueyue Shao, Kehan Wang, Zhiyu Tang‐Yang, Hanzhi Zang, Yuwen Du, Anran Dong, Jinxiong Feng, Jiayun Chen, Ying Zheng, Xiaofang Tan, Xiaoyu Zhao, Zhonghua Shi, Bo Zheng, Jun Yu   +23 more
wiley   +1 more source

Vitamin B-12 and folate deficiency in chronic heart failure

, 2015
Objective To determine the prevalence, clinical correlates and the effects on outcome of vitamin B-12 and folic acid levels in patients with chronic heart failure (HF).
Grote Beverborg, Niels; id_orcid, Klip, Ijsbrand T., Ponikowski, Piotr, Voors, Adriaan A., Bruguera, Jordi, Jankowska, Ewa A., Grote Beverborg, Niels, Comin-Colet, Josep, Banasiak, Waldemar, van der Wal, Haye H., Enjuanes, Cristina, van Veldhuisen, Dirk J., van der Meer, Peter   +12 more
core   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Can food-based strategies help reduce vitamin A and iron deficiencies? [PDF]

Micronutrient malnutrition is still a problem of unacceptable proportions in developing countries. Iron and vitamin A deficiencies are the most widespread nutrition deficiencies in the world today, affecting perhaps as many as 3.5 billion people ...
Ruel, Marie T.
core  

Optic neuropathy as a presenting feature of vitamin B-12 deficiency: A systematic review of literature and a case report. [PDF]

Ann Med Surg (Lond), 2020
Ata F, Bint I Bilal A, Javed S, Shabir Chaudhry H, Sharma R, Fatima Malik R, Choudry H, Bhaskaran Kartha A.   +7 more
europepmc   +1 more source