Advanced Science, EarlyView.Glucocorticoid‐induced osteoporosis (GIOP) triggers osteocyte ferroptosis via SLC7A11 degradation. PSMD14 stabilizes SLC7A11 by counteracting glucocorticoid‐driven ubiquitination, preserving cystine uptake and glutathione synthesis. AAV‐mediated PSMD14 delivery or its agonist Pantethine rescues osteocyte survival and bone loss in GIOP mice.
Yifeng Shi +20 more
wiley +1 more source
Magnetic resonance imaging findings within the posterior and lateral columns of the spinal cord extended from the medulla oblongata to the thoracic spine in a woman with subacute combined degeneration without hematologic disorders: a case report and review of the literature [PDF]
, 2011 Introduction Subacute combined degeneration of the spinal cord is a rare cause of demyelination of the dorsal and lateral columns of the spinal cord and is a neurological complication of vitamin B12 deficiency.
AH Karantanas +16 more
core +3 more sources
Background:Cognitive health is a public health concern among older adults. Dietary supplement (SUP) use is common and concerns have been raised about high folic acid intake among those with vitamin B-12 deficiency and exacerbation of poor cognitive ...
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Enhanced Activities of OCT4 and SOX2 Promote Epigenetic Reprogramming by Shortening G1 Phase
Advanced Science, EarlyView.Fusing the VP16 domain to OCT4 and SOX2 (OvSvK) enhances iPSC generation by activating downstream targets, including those regulating the cell cycle. This accelerates reprogramming by shortening the G1 phase and reducing H3K27me3 levels. Modulating Ccnd1, Cdkn2a, and Ccne1 improves efficiency, linking cell cycle to epigenetic remodeling.
Lin Guo +17 more
wiley +1 more source
Advanced Science, EarlyView.Conjugated microporous polymer membranes with narrowly distributed network pores are prepared by diffusion‐modulated electropolymerization. This approach precisely controls the monomer diffusion and coupling processes, regulating the crosslinking degree to prevent broad aggregate pores and microporous defects.
Yanqiu Lu +4 more
wiley +1 more source
Advanced Science, EarlyView.We developed a citramalate‐derived pathway for 2‐methylbutyric acid production in E. coli mono‐culture and consortia. The optimized consortium, using 2‐keto‐3‐methylvalerate as a node, achieved 1817.03 ± 103.73 mg L−1 2‐methylbutyric acid, a 28‐fold increase from the initial strain, with a yield of 0.091 g/g glucose.
Yu Liu +3 more
wiley +1 more source
Vitamin D supplementation in patients with Crohn’s Disease and vitamin D deficiency: D-CODE feasibility study. An open label feasibility study for a randomised controlled trial [PDF]
, 2023 Introduction: Crohn’s Disease (CD) is one form of Inflammatory Bowel Disease (IBD) characterised by severe diarrhoea, abdominal pain, and nutritional problems.
Fletcher, Jane
core
Diphyllobothrium latum and human nutrition, with particular reference to vitamin B12deficiency [PDF]
, 1963 Wolmar Nyberg
openalex +1 more source
Advanced Science, EarlyView.In people with overweight or obesity, regular exercise even without weight loss or vitamin D supplementation completely prevents the usual winter decline in the vitamin D metabolite that maintains health at a cellular level, 1,25(OH)2D3, and ameliorates the decline in the vitamin D status marker 25(OH)D.
Oliver J. Perkin +11 more
wiley +1 more source
Hygienic risk assessment of children with somatic health problems associated with vitamin deficiency
Analiz Riska Zdorovʹû, 2015 A study of the seasonal provision of children attending pre-school organizations that implement the standard artificial diet fortification with vitamins A, C, D, E, В 6 and B 12 was performed.
O.J. Ustinova +3 more
doaj +1 more source