Results 41 to 50 of about 20,924,698 (293)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Development and Validation of a Quantitative Analysis of Water-Soluble Vitamins Using High-Performance Thin-Layer Chromatography and Its Application to the Analysis of Nutraceuticals

Separations
In this study, a high-performance thin-layer chromatography (HPTLC)-based method was developed for the quantification of five water-soluble vitamins, B2, B3, B6, B12, and C, using ethanol–water (70:30, v/v) as the mobile phase.
K. M. Yasif Kayes Sikdar, Md Khairul Islam, Tomislav Sostaric, Lee Yong Lim, Cornelia Locher   +4 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Relation between vitamin D deficiency and benign paroxysmal positional vertigo

Scientific Reports, 2021
Benign paroxysmal positional vertigo (BPPV) is the most common cause of positional vertigo. Vitamin D deficiency may be one of the causes of its development. To assess the relation between recurrent attacks BPPV and Vitamin D deficiency.
Aida Ahmed Abdelmaksoud, Dalia Fahim Mohammed Fahim, Shamardan Ezzeldin Sayed Bazeed, Mohamed Farouk Alemam, Zaki Farouk Aref   +4 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Does taking vitamin, mineral and fatty acid supplements prevent cognitive decline? A systematic review of randomized controlled trials [PDF]

, 2008
Background Observational studies have shown associations between nutritional status and cognition in later life but evidence from intervention studies is unclear.
McNeill, G, Jia, X, Avenell, Alison
core   +2 more sources

A Synthesis of Vitamin B ₆

Agricultural and Biological Chemistry, 1961
In the presence of basic catalyst condensation of dehydrolevulinate and cyanoacetamide afforded ethyl 2-methyl-5-cyano-6-pyridone-4-carboxylate [IV]. Starting from [IV], a total synthesis of vitamin B6 was described.
MATSUI, Masanao, KOBAYASHI, Akio, WATANABE, Suzuo   +2 more
openaire   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Vitamin D with calcium reduces mortality: patient level pooled analysis of 70,528 patients from eight major vitamin D trials. [PDF]

, 2012
Introduction: Vitamin D may affect multiple health outcomes. If so, an effect on mortality is to be expected. Using pooled data from randomized controlled trials, we performed individual patient data (IPD) and trial level meta-analyses to assess ...
Salovaara, K., Smith, H.E., Jackson, Rebecca D, Sanders, Kerrie M., Jacobs, ET, Rebecca D Jackson (16135031), Sanders, KM, Tahir Masud (804313), Jacobs, E.T., JoAnn E Manson (13567339), Robbins, John A., Salovaara, K, Haakon E Meyer (10282121), Rejnmark, Lars, Abrahamsen, Bo, Jackson, Rebecca D., Mosekilde, Leif, Brixen, K., Mosekilde, L., Robbins, JA, Cyrus Cooper (141250), Lars Rejnmark (3752971), Mosekilde, L, Elizabeth T Jacobs (16135028), Bo Abrahamsen (650396), Meyer, Haakon E., Jackson, RD, Alison Avenell (82040), Jacobs, Elizabeth T., Smith, Helen E, Abrahamsen, Bo; id_orcid, Brixen, K, Salovaara, Kari, Manson, Joann E, Torgerson, D., Robbins, J.A., Avenell, A, Robbins, John A, Francis, Roger M., Roger M Francis (7380278), Abrahamsen, B, Masud, T, Jacobs, Elizabeth T, Manson, JoAnn E., Anderson, F., Francis, R.M., Kerrie M Sanders (13488952), Francis, RM, David Torgerson (462403), Masud, T., Helen E Smith (16045475), Abrahamsen, B., Manson, J.E., Cooper, Cyrus, Sanders, K.M., Frazer Anderson (16135022), Meyer, Haakon E, Anderson, F, Torgerson, D, Kari Salovaara (16135025), Meyer, H.E., Rejnmark, L, Francis, Roger M, John A Robbins (8553495), Torgerson, David, Masud, Tahir, Smith, HE, Anderson, Frazer, Cooper, C., Meyer, HE, Kim Brixen (16135034), Jackson, R.D., Smith, Helen E., Cooper, C, Rejnmark, L., Manson, JE, Avenell, Alison, Avenell, A., Brixen, Kim, Leif Mosekilde (349340), Sanders, Kerrie M   +80 more
core   +1 more source