Results 41 to 50 of about 450,569 (260)

Adjunctive Multicomponent Crystals of Two Anti-Tubercular Drugs with Pyridoxine

Pharmaceutics
Background/Objectives: Cocrystallisation is a well-established path for altering the physicochemical properties and bioavailability of active pharmaceutical ingredients (APIs). A common side effect of anti-tubercular medicines is the depletion of group B
Tsebang A. Matlapeng, Theodor E. Geswindt, Roderick B. Walker, Vincent J. Smith   +3 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Study on the immunomodulatory mechanism of vitamin D in patients with unexplained recurrent spontaneous abortion

Heliyon
Background: To investigate the mechanism of vitamin D level on the regulation of peripheral blood lymphocyte subsets and serum Th1/Th2 cytokines in patients with unexplained recurrent spontaneous abortion (URSA). Methods: Eighty female patients with URSA
Panyu Yang, Fenjian Lu
doaj   +1 more source

Vitamin D, low birthweight preterm and full-term newborns: time for a paradigm shift [PDF]

РМЖ. Мать и дитя, 2020
I.N. Zakharova1, S.V. Mal’tsev1, V.V. Zubkov2, V.A. Kur’yaninova3, A.V. Dmitriev1,4, S.I. Malyavskaya5, L.I. Mal’tseva6, N.E. Verisokina3, L.Ya. Klimov3, E.N. Vasil’eva7, A.A. Krushel’nitskiy1, A.V.&
I.N. Zakharova, S.V. Mal’tsev, V.V. Zubkov, V.A. Kur’yaninova, A.V. Dmitriev, S.I. Malyavskaya, L.I. Mal’tseva, N.E. Verisokina, L.Ya. Klimov, E.N. Vasil’eva, A.A. Krushel’nitskiy, A.V. Makhaeva, E.D. Zhdakaeva, A.L. Zaplatnikov   +13 more
doaj  

Biosynthesis of Vitamin B6

Journal of Biological Chemistry, 1972
The biosynthesis of vitamin B6 was studied in an Escherichia coli mutant, blocked between pyridoxol and pyridoxal. Specific incorporation of glycerol, pyruvate, serine, and glucose was shown by chemical degradation of labeled samples of pyridoxol isolated from the medium of cultures which had been incubated with various 14C-labeled radiomers of these ...
R E, Hill, F J, Rowell, R N, Gupta, I D, Spenser   +3 more
openaire   +2 more sources

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Synthesis of 23,23-Difluoro-24-nor- and 24′,24′-Difluoro-24-Homovitamin D₃ Analogues and Unexpected Structure-Activity Relationships

Organics
We synthesized two vitamin D3 analogues, 3 and 4, which have a shortened or elongated fluoro-side-chain based on 24,24-difluoro-25-hydroxyvitamin D3 (5) using an efficient convergent approach and studied their preliminary biological activity.
Fumihiro Kawagoe, Hiroya Tabuchi, Taiyo Ideguchi, Yuki Okamoto, Souma Murata, Tomofumi Yatsu, Syota Yamada, Kaori Yasuda, Yusuke Akagi, Masashi Takano, Toshie Fujishima, Yoshiki Miyata, Ken’ichi Aoki, Toshiyuki Sakaki, Atsushi Kittaka   +14 more
doaj   +1 more source

Effect of Sodium Tripolyphosphate, Glycerol, Vitamin B2, Mannitol and Solid Malt Extract on Survival of Bifidobacterium bifidum During Freeze-Drying

Acta Universitatis Cibiniensis. Series E: Food Technology, 2019
The effect of sodium tripolyphosphate, glycerol, vitamin B2, mannitol and solid malt extract on the freeze-dried powder survival rate and the viable cells of the B. bifidum BB01 were studied by single-factor test in this study.
Shu Guowei, Yin Chun, Qin Haipeng, Kou Haiyan, He Shuai, Huang Dan   +5 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source