Results 41 to 50 of about 86,313,599 (295)

Vitamin D supplementation in patients with diabetes mellitus type 2 on different therapeutic regimens : a one-year prospective study [PDF]

, 2013
Background Little or no research has determined the effect of vitamin D3 supplementation in conjunction with pharmacological and non-pharmacological approaches in the diabetes mellitus type 2 (DMT2) patients. The objective of this study was to determine
Majed S Alokail, Al-Othman, Abdulaziz, Osama Moharram, Yousef Al-Saleh, Shaun B Sabico, Chrousos, George P., Kumar, Sudhesh, Sabico, Shaun, Abdulaziz Al-Othman, Nasser M Al-Daghri, Sudhesh Kumar, George P Chrousos, Alokail, Majed S., Al-Daghri, Nasser M., Al-Saleh, Yousef, Moharram, Osama, Alkharfy, Khalid M., Khalid M Alkharfy   +17 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Functional Improvement in Geriatric Hip Fractures

Geriatric Orthopaedic Surgery & Rehabilitation, 2015
Introduction: The “Integrated Care Pathway” for geriatric intertrochanteric (IT) fractures in Singapore’s Tan Tock Seng Hospital has shown significant functional recovery in patients’ activities of daily living.
W. R. D. Seng MBChB, MRCS(Glasg), M. H. Belani, R. Ramason MBChB (Leeds), MRCP (UK), DGM (London), G. Naidu MBBS, FRCS (Edin), FRCS (Edin) (Ortho), FAMS (Ortho), H. K. Doshi Bac. Med. Sc, M.D. (M'sia), MRCS (Ed), AFRCSI (Dublin), FRCS Ed (Ortho), FEBOT (Europe), M.Med.Ortho (S'pore), Dip SICOT (Belgium)   +4 more
doaj   +1 more source

Effect of vitamin D on the pregnancy and the health of newborns and infants: state-of-the-art [PDF]

РМЖ. Мать и дитя, 2020
I.N. Zakharova1, S.V. Mal’tsev1, V.V. Zubkov2, V.A. Kur’yaninova3, A.V. Dmitriev4, L.I. Mal’tseva5, N.E. Verisokina3, L.Ya. Klimov3, E.N. Vasil’eva6, S.I. Malyavskaya7, A.L.
I.N. Zakharova, S.V. Mal’tsev, V.V. Zubkov, V.A. Kur’yaninova, A.V. Dmitriev, L.I. Mal’tseva, N.E. Verisokina, L.Ya. Klimov, E.N. Vasil’eva, S.I. Malyavskaya, A.L. Zaplatnikov   +10 more
doaj  

A Synthesis of Vitamin B ₆

Agricultural and Biological Chemistry, 1961
In the presence of basic catalyst condensation of dehydrolevulinate and cyanoacetamide afforded ethyl 2-methyl-5-cyano-6-pyridone-4-carboxylate [IV]. Starting from [IV], a total synthesis of vitamin B6 was described.
MATSUI, Masanao, KOBAYASHI, Akio, WATANABE, Suzuo   +2 more
openaire   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Blood plasma B vitamins in depression and the therapeutic response to electroconvulsive therapy

Brain, Behavior, & Immunity - Health, 2020
A growing body of research has indicated a role for B vitamins in depression, with some previous studies suggesting that B vitamin status in patients with depression can impact on antidepressant response.
Karen M. Ryan, Kelly A. Allers, Andrew Harkin, Declan M. McLoughlin   +3 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Adjunctive Multicomponent Crystals of Two Anti-Tubercular Drugs with Pyridoxine

Pharmaceutics
Background/Objectives: Cocrystallisation is a well-established path for altering the physicochemical properties and bioavailability of active pharmaceutical ingredients (APIs). A common side effect of anti-tubercular medicines is the depletion of group B
Tsebang A. Matlapeng, Theodor E. Geswindt, Roderick B. Walker, Vincent J. Smith   +3 more
doaj   +1 more source

Biosynthesis of Vitamin B6

Journal of Biological Chemistry, 1972
The biosynthesis of vitamin B6 was studied in an Escherichia coli mutant, blocked between pyridoxol and pyridoxal. Specific incorporation of glycerol, pyruvate, serine, and glucose was shown by chemical degradation of labeled samples of pyridoxol isolated from the medium of cultures which had been incubated with various 14C-labeled radiomers of these ...
R E, Hill, F J, Rowell, R N, Gupta, I D, Spenser   +3 more
openaire   +2 more sources