Results 51 to 60 of about 86,313,599 (295)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Stable isotope dilution techniques for assessing vitamin A status and bioefficacy of provitamin A carotenoids in humans. [PDF]

, 2005
Vitamin A deficiency is a major global public health problem. Among the variety of techniques that are available for assessing human vitamin A status, evaluating the provitamin A nutritional values of foodstuffs and estimating human vitamin A ...
Judy D Ribaya-Mercado, Emorn Wasantwisut, Marjorie Haskell, Sherry Tanumihardjo, Harold C Furr, Wasantwisut, Emorn, Tang, Guangwen, Penelope Nestel, Sam Newton, Guangwen Tang, Haskell, Marjorie, Ribaya-Mercado, Judy D, Najat Mokhtar, Furr, Harold C, Nestel, Penelope, Newton, Sam, Tanumihardjo, Sherry, Green, Michael H, Michael H Green, Mokhtar, Najat   +19 more
core   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Proxy markers of serum retinol concentration, used alone and in combination, to assess population vitamin A status in Kenyan children: a cross-sectional study [PDF]

, 2015
Background Serum retinol concentration determined by high-performance liquid chromatography (HPLC) is recommended by the World Health Organization to assess population vitamin A status.
Inge D Brouwer, Verhoef, H., Elise F Talsma, Alida Melse-Boonstra, Brouwer, Inge D, Hulshof, Paul JM, Talsma, E.F., Anne S Mburu-de Wagt, Paul JM Hulshof, Hans Verhoef, Talsma, Elise F, Mburu-de Wagt, Anne S, Melse-Boonstra, Alida, Brouwer, I.D., Hulshof, P.J.M., Mburu-de Wagt, A.S., Verhoef, Hans, Boonstra, A., Talsma, E.F.; Verhoef, H.; Brouwer, I.D.; Mburu-de Wagt, A.S.; Hulshof, P.J.M.; Melse-Boonstra, A.   +18 more
core   +2 more sources

Study on the immunomodulatory mechanism of vitamin D in patients with unexplained recurrent spontaneous abortion

Heliyon
Background: To investigate the mechanism of vitamin D level on the regulation of peripheral blood lymphocyte subsets and serum Th1/Th2 cytokines in patients with unexplained recurrent spontaneous abortion (URSA). Methods: Eighty female patients with URSA
Panyu Yang, Fenjian Lu
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Inflammation causes tissue-specific depletion of vitamin B-6 [PDF]

, 2005
Previously we observed strong and consistent associations between vitamin B-6 status and several indicators of inflammation in patients with rheumatoid arthritis.
Selhub, J., Roubenoff, Ronenn, Chiang, Eugene, Chiang, E.P., Smith, D.E., Smith, Donald, Selhub, Jacob, Roubenoff, R., Dallal, Gerard, Wang, Yi-Cheng, Dallal, G., Wang, Y.C.   +11 more
core   +1 more source

Synthesis of 23,23-Difluoro-24-nor- and 24′,24′-Difluoro-24-Homovitamin D₃ Analogues and Unexpected Structure-Activity Relationships

Organics
We synthesized two vitamin D3 analogues, 3 and 4, which have a shortened or elongated fluoro-side-chain based on 24,24-difluoro-25-hydroxyvitamin D3 (5) using an efficient convergent approach and studied their preliminary biological activity.
Fumihiro Kawagoe, Hiroya Tabuchi, Taiyo Ideguchi, Yuki Okamoto, Souma Murata, Tomofumi Yatsu, Syota Yamada, Kaori Yasuda, Yusuke Akagi, Masashi Takano, Toshie Fujishima, Yoshiki Miyata, Ken’ichi Aoki, Toshiyuki Sakaki, Atsushi Kittaka   +14 more
doaj   +1 more source

Vitamin D, low birthweight preterm and full-term newborns: time for a paradigm shift [PDF]

РМЖ. Мать и дитя, 2020
I.N. Zakharova1, S.V. Mal’tsev1, V.V. Zubkov2, V.A. Kur’yaninova3, A.V. Dmitriev1,4, S.I. Malyavskaya5, L.I. Mal’tseva6, N.E. Verisokina3, L.Ya. Klimov3, E.N. Vasil’eva7, A.A. Krushel’nitskiy1, A.V.&
I.N. Zakharova, S.V. Mal’tsev, V.V. Zubkov, V.A. Kur’yaninova, A.V. Dmitriev, S.I. Malyavskaya, L.I. Mal’tseva, N.E. Verisokina, L.Ya. Klimov, E.N. Vasil’eva, A.A. Krushel’nitskiy, A.V. Makhaeva, E.D. Zhdakaeva, A.L. Zaplatnikov   +13 more
doaj  

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source