Results 211 to 220 of about 92,834,848 (305)

Pathophysiological Mechanisms of Emaciation Syndrome in Plectropomus leopardus: Insights From Histology and Transcriptomics

open access: yesAnimal Research and One Health, EarlyView.
Integrated phenotypic, histological, transcriptomic, and validation analyses reveal that emaciation syndrome in Plectropomus leopardus is associated with intestinal structural damage, hepatic metabolic remodeling, and muscle protein degradation, highlighting coordinated multi‐tissue alterations underlying disease progression.
Zhihao Zhang   +11 more
wiley   +1 more source

Beyond Protein Synthesis: The Multifunctional Role of Functional Amino Acids in Modulating Meat Quality in Ruminants

open access: yesAnimal Research and One Health, EarlyView.
Multifunctional roles of functional amino acids in regulating meat quality in ruminants: Functional amino acids (FAAs) regulate ruminant meat quality through multiple interconnected mechanisms, including antioxidant protection, metabolic regulation, signal transduction, structural support, and gene expression modulation.
Zixin Liu   +5 more
wiley   +1 more source

T cells, the Next Big Target in Axial Spondyloarthritis?

open access: yesArthritis &Rheumatology, EarlyView.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source

Increased Plasma Microbial tDR‐1 in At‐Risk Individuals Is Associated With Decreased Conversion to Clinical Rheumatoid Arthritis and Reduces an In Vitro Macrophage Type 1 Interferon Response

open access: yesArthritis &Rheumatology, EarlyView.
Objective Microbial small RNAs can regulate human genes. Higher plasma concentrations of microbial transfer RNA (tRNA)‐derived RNA‐1 (tDR‐1) were previously associated with lower rheumatoid arthritis (RA) disease activity. This study examined whether tDR‐1 concentrations differ in anticyclic citrullinated peptide‐3 positive (CCP3+) at‐risk individuals (
Anastasiia Phothisane   +11 more
wiley   +1 more source

Vitamin-B12 status among the mother-infant dyad: an explorative overview in a single centre in Lombardy. [PDF]

open access: yesFront Nutr
Furlan F   +14 more
europepmc   +1 more source

Clinical relevance of pharmacogenomic information for improving prescribing practices in acutely admitted older medical patients

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Safe prescribing and effective medication review during acute hospitalization depends on accurate information about liver and kidney function because these organs are responsible for the elimination of most medications. While estimates for kidney function are widely used, comparable markers of hepatic drug‐metabolizing capacity are not routinely ...
Louise Westberg Strejby Christensen   +17 more
wiley   +1 more source

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