Results 41 to 50 of about 496,870 (263)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
BIOS, 2021 Vitamin-C is a kind of water-soluble vitamins and can improve the body's resistance to disease. Vitamin-C can be found in various types of food such as vegetables and fruit.
Siti Ernawati, Wardah Ramadhanty
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Pengaruh Kadar Vitamin C dan Vitamin E Terhadap Peningkatan Kadar Bilirubin pada Neonatus
Sari Pediatri, 2016 Latar belakang. Hiperbilirubinemia terjadi pada 25%-50% bayi baru lahir. Secara fisiologis bilirubin meningkat mencapai puncak pada kadar 5-6 mg/dl pada hari 3-4 setelah kelahiran, penyebab terbanyak karena hemolisis (75%) akibat pendeknya usia eritrosit
Kamilah Budhi Rahardjani +2 more
doaj +1 more source
The Pharmacokinetics of Vitamin C [PDF]
Nutrients, 2019 The pharmacokinetics of vitamin C (vitC) is indeed complex. Regulated primarily by a family of saturable sodium dependent vitC transporters (SVCTs), the absorption and elimination are highly dose-dependent. Moreover, the tissue specific expression levels and subtypes of these SVCTs result in a compartmentalized distribution pattern with a diverse range
Jens Lykkesfeldt, Pernille Tveden-Nyborg
openaire +3 more sources
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model
FEBS Open Bio, EarlyView.This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito +7 more
wiley +1 more source
Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley +1 more source
Anti-oxidant Status in Patients with Chronic Hepatitis C in Rajasthan, India [PDF]
Journal of Clinical and Diagnostic Research, 2012 Background/Aims: Hepatitis C is a global disease and being endemic in India, it is one of the most important causes of chronic liver disease and furthermore, it is related to carcinogenesis.
Santosh K Sharma +2 more
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