Results 51 to 60 of about 181,889 (303)

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Low vitamin C concentrations and prognosis in critically ill children [PDF]

Acute and Critical Care
Background The administration of high-dose vitamins has been focused on in critically ill patients as adjunctive therapy for life-threatening conditions. We evaluated the association between serum vitamin C concentrations and patient prognosis.
Min Jung Kim, Yoon Hee Kim, Soo Yeon Kim, Jong Deok Kim, Mireu Park, Hamin Kim, Myung Hyun Sohn, Kyung Won Kim   +7 more
doaj   +1 more source

Vitamin D, innate immunity and outcomes in community acquired pneumonia

, 2011
We investigated the associations between vitamin D status, the antimicrobial peptides cathelicidin and beta defensin-2 and outcomes in community acquired pneumonia.
Karalus, Noel, LEONG LEOW, Cursons, Raymond T., RAY CURSONS, Hancox, Robert J., Leow, Leong, NOEL KARALUS, ROBERT J. HANCOX, TALIA SIMPSON, Leong, Talia   +9 more
core   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

The role of inflammation and oxidative stress in the pathophysiology of depressions: time to consider vitamin C deficiency

Exploration of Neuroscience
Depression is on the rise and medication does not always provide satisfactory relief. This raises the question of a treatment gap that has not yet been (sufficiently) addressed. Inflammation and oxidative stress play an important pathophysiological role,
Claudia Vollbracht, Marc Werner
doaj   +1 more source

Low vitamin D status adversely affects bone health parameters in adolescents

, 2008
Background: The effects of subclinical vitamin D deficiency on bone mineral density (BMD) and bone turnover in adolescents, especially in boys, are unclear.Objective: We aimed to investigate the relations of different stages of vitamin D status and BMD ...
Cashman, Kevin D, Tom R Hill, Robson, Paula J, Kiely, Mairead, Wallace, Julie MW, Werner Dubitzky, Flynn, Albert, Dubitzky, Werner, Kevin D Cashman, Liam Murray, Paula J Robson, Julie MW Wallace, Colin A Boreham, JJ Strain, Cotter, Alice A, Albert Flynn, Mairead Kiely, Strain, J J, Boreham, Colin A, Hill, Tom R, Murray, Liam, Alice A Cotter   +21 more
core   +1 more source

Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation [PDF]

, 2011
Deficiency of vitamin D is associated with accelerated decline in lung function. Vitamin D is a ligand for nuclear hormone vitamin D receptor (VDR), and upon binding it modulates various cellular functions.
Wu, Shaoping, Jae-Woong Hwang, Sundar, Isaac K, Sun, Jun, Isaac K. Sundar, Hwang, Jae-woong, Rahman, Irfan, Shaoping Wu, Irfan Rahman, Jun Sun   +9 more
core   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Hospital admissions for vitamin D related conditions and subsequent immune-mediated disease: record-linkage studies.

, 2013
BACKGROUND: Previous studies have suggested that there may be an association between vitamin D deficiency and the risk of developing immune-mediated diseases.
Giulio Disanto, Michael J Goldacre, Goldacre, R, Sreeram V Ramagopalan, Gavin Giovannoni, Raph Goldacre, Ramagopalan, SV, Goldacre, MJ, Goldacre, Michael, Giovannoni, G, Disanto, G   +10 more
core   +1 more source

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source