Results 41 to 50 of about 19,174,629 (255)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Prenatal Vitamin D supplementation and child respiratory health: a randomised controlled trial [PDF]

, 2013
Background Observational studies suggest high prenatal vitamin D intake may be associated with reduced childhood wheezing. We examined the effect of prenatal vitamin D on childhood wheezing in an interventional study.
Hooper Richard, Richard Hooper, Shaheen Seif O., Warner, JO, Adrian R. Martineau (136644), Poulton, S, Martineau, AR, Goldring, ST, Seif O. Shaheen (177559), Yu, C, Sheree Poulton, Janet Stocks (425915), Christina Yu, Stephen Robinson, Griffiths, CJ, Boyle, RJ, Hooper, R, Kirkby Jane C., Robinson Stephen, Robert J Boyle, Stephen T Goldring, Martineau Adrian R., Warner John O., John O Warner, Goldring Stephen T., Yu Christina, Stocks, J, Chris J. Griffiths (425910), Stocks Janet, Boyle Robert J., Jane C. Kirkby (425914), Janet Stocks, Richard Hooper (425916), Kirkby, JC, Christina Yu (425912), Stephen Robinson (425911), Robinson, S, Shaheen, SO, Jane C Kirkby, Stephen T. Goldring (425909), Poulton Sheree, John O. Warner (425917), Adrian R Martineau, Seif O Shaheen, Robert J. Boyle (425918), Griffiths Chris J., Chris J Griffiths, Sheree Poulton (425913)   +47 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Vitamin C Deficiency

The health of the body is strongly influenced by the nutrients in food, including vitamins and minerals crucial for supporting energy levels and overall stability. Vitamin C, in particular, plays a significant role in the body’s ability to resist contamination from heavy metals present in consumed food, thereby affecting the organ’s capacity to defend ...
Kaushik Das, Ajanta Nayak, Farheen Parveen   +2 more
openaire   +2 more sources

Effectiveness of the National Program of Complementary Feeding for older adults in Chile on vitamin B12 status in older adults; secondary outcome analysis from the CENEX Study (ISRCTN48153354). [PDF]

, 2013
BACKGROUND: Older people are at increased risk of vitamin B12 deficiency and the provision of fortified foods may be an effective way to ensure good vitamin B12 status in later life.
Sánchez Reyes, Hugo, Albala Brevis, Cecilia, Uauy, Ricardo, Alan D Dangour, Cecilia Albala, Lera, Lydia, Hugo Sanchez, Sanchez, Hugo, Lydia Lera, Uauy Dagach-Imbarack, Ricardo, Dangour, Alan D., Lera Marques, Lydia, Dangour, Alan D, Ricardo Uauy, Hugo HugoSanchez, Albala, Cecilia   +15 more
core   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Scurvy with Musculoskeletal Pain in Indonesian Pediatric Patient: A Case Report

Jurnal Kedokteran Diponegoro
Background: Scurvy is a potentially fatal disease caused by a severe deficiency of vitamin C, which can manifest as a musculoskeletal problem. Early diagnosis and treatment of vitamin C deficiency are crucial to prevent severe symptoms.
Hilmi Muhammad, Meirizal Meirizal, Yudha Mathan Sakti, Aditya Fuad Robby Triangga, Zikrina Abiyanti Lanodiyu, Ginanjar Reza Putra, Yasser Yasser, Yuni Artha Prabowo Putro   +7 more
doaj   +1 more source

Comparative analysis of vitamin D contents in patients with chronic viral hepatitis C and healthy.

Medičnì Perspektivi, 2019
From scientific literature it is known that vitamin D helps maintain the most important functions of the immune system, there is evidence of its role in inflammatory and metabolic diseases of the liver, including infection with hepatitis C.
L. L. Shostakovych-Koretskaya, M. A. Nikolaychuk, I. V. Budayeva, O. P. Shevchenko-Makarenko, K. Yu. Lytviy, S. V. Biletska   +5 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Low vitamin C concentrations and prognosis in critically ill children [PDF]

Acute and Critical Care
Background The administration of high-dose vitamins has been focused on in critically ill patients as adjunctive therapy for life-threatening conditions. We evaluated the association between serum vitamin C concentrations and patient prognosis.
Min Jung Kim, Yoon Hee Kim, Soo Yeon Kim, Jong Deok Kim, Mireu Park, Hamin Kim, Myung Hyun Sohn, Kyung Won Kim   +7 more
doaj   +1 more source