Results 81 to 90 of about 16,822,925 (382)

Vitamin D Intoxication [PDF]

Acta Paediatrica, 1955
Vitamin D intoxication (VDI) may result from supplementation rarely, but it has been reported more frequently in recent years. This may be attributable to an increase in vitamin D supplement intake due to an understanding of the role of vitamin D (25OHD) in the pathogenesis of several diseases.
Ozkan, Behzat, BEREKET, ABDULLAH, Hatun, Sukru   +2 more
openaire   +4 more sources

Micronutrient Intakes and Status in the Protein Transition: A Systematic Review

Proceedings
A food systems transformation is required to improve both human and planetary health. A reduction in the consumption of high-impact animal-based foods will be necessary, especially in high-income settings. Ensuring nutritional adequacy in this transition
Ursula M. Leonard, Clarissa L. Leydon, Elena Arranz, Mairead E. Kiely   +3 more
doaj   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Evidence Regarding Vitamin D and Risk of COVID-19 and Its Severity

Nutrients, 2020
Vitamin D deficiency co-exists in patients with COVID-19. At this time, dark skin color, increased age, the presence of pre-existing illnesses and vitamin D deficiency are features of severe COVID disease.
J. Mercola, W. Grant, C. Wagner
semanticscholar   +1 more source

Darker Skin Color Measured by Von Luschan Chromatic Scale and Increased Sunlight Exposure Time Are Independently Associated with Decreased Odds of Vitamin D Deficiency in Thai Ambulatory Patients

Journal of Nutrition and Metabolism, 2021
Background. Little is known about the association among skin color, sunlight exposure. and vitamin D status in Southeast Asian population. Objective. To investigate the association between skin color measured by von Luschan chromatic scale (VLCS) and ...
Nipith Charoenngam, Sutin Sriussadaporn
doaj   +1 more source

Vitamin D supplementation to prevent acute respiratory infections: systematic review and meta-analysis of aggregate data from randomised controlled trials

medRxiv, 2020
Objectives: To assess the overall effect of vitamin D supplementation on risk of acute respiratory infection (ARI), and to identify factors modifying this effect.
David A. Jolliffe, C. Camargo, J. Sluyter, M. Aglipay, J. Aloia, D. Ganmaa, P. Bergman, A. Borzutzky, C. T. Damsgaard, G. Dubnov-Raz, S. Esposito, C. Gilham, A. Ginde, Inbal Golan-Tripto, E. Goodall, C. Grant, C. Griffiths, A. Hibbs, W. Janssens, A. Khadilkar, I. Laaksi, Margaret T. Lee, M. Loeb, J. Maguire, P. Majak, D. Mauger, S. Manaseki-Holland, D. Murdoch, Akio Nakashima, R. Neale, H. Pham, Christine Rake, J. Rees, Jenni Rosendahl, R. Scragg, D. Shah, Yoshiki Shimizu, S. Simpson-Yap, G. Kumar, M. Urashima, A. Martineau   +40 more
semanticscholar   +1 more source