Results 101 to 110 of about 149,521 (328)

Pharmacokinetics and Bioequivalence of a Novel Extended‐Release Formulation of Methylphenidate Hydrochloride for Attention‐Deficit/Hyperactivity Disorder

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Extended‐release (ER) formulations of the stimulant methylphenidate are commonly used to treat attention‐deficit/hyperactivity disorder in both children and adults. Previous studies have shown that the clinical effectiveness of long‐acting methylphenidate formulations is closely tied to the drug's pharmacokinetic (PK) profile, highlighting the
Ann C. Childress, Ahmad AL‐Sabbagh, Jeffrey H. Newcorn   +2 more
wiley   +1 more source

Vitamin D3 Activates Phosphatidylinositol-3-Kinase/Protein Kinase B via Insulin-Like Growth Factor-1 to Improve Testicular Function in Diabetic Rats

Journal of Diabetes Research, 2019
Objective. In diabetes mellitus, vitamin D3 deficiency affects sex hormone levels and male fertility; however, the mechanism leading to the disorder is unclear.
Yanyan He, Yang Liu, Qing-Zhu Wang, Feng Guo, Fengjuan Huang, Linlin Ji, Tingting An, Guijun Qin   +7 more
doaj   +1 more source

Scientific Opinion on the safety and efficacy of vitamin D₃ (cholecalciferol) as a feed additive for all animal species or categories based on a dossier submitted by Lohmann Animal Health GmbH [PDF]

, 2014
The principal physiological role of vitamin D in all vertebrates is in calcium and phosphorus homeostasis. The classic clinical deficiency syndrome is rickets.
Aburto, Aburto, Aburto, AWT (Arbeitsgemeinschaft für Wirkstoffe in der Tierernährung e.V.), EFSA (European Food Safety Authority), EFSA (European Food Safety Authority), EFSA (European Food Safety Authority), EFSA (European Food Safety Authority), EFSA (European Food Safety Authority), EFSA (European Food Safety Authority), EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed), EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed), EFSA NDA Panel (EFAS Panel on Dietetic Products, Nutrition and Allergies), EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), European Pharmacopoeia (PhEur), European Pharmacopoeia (PhEur), European Pharmacopoeia (PhEur), European Pharmacopoeia (PhEur), GfE (Gesellschaft für Ernährungsphysiologie), GfE (Gesellschaft für Ernährungsphysiologie), GfE (Gesellschaft für Ernährungsphysiologie), GfE (Gesellschaft für Ernährungsphysiologie), GfE (Gesellschaft für Ernährungsphysiologie), GfE (Gesellschaft für Ernährungsphysiologie), IPCS (International Programme on Chemical Safety), Jakobsen, Mattila, Mattila, NRC (National Research Council), NRC (National Research Council), NRC (National Research Council), NRC (National Research Council), NRC (National Research Council), NRC (National Research Council), NRC (National Research Council), NRC (National Research Council), NRC (National Research Council), Souci, Whitehead, Whittemore   +45 more
core   +1 more source

Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi‐Omics and Multi‐Modal Data Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu, Hui Shen, Jonathan Greenbaum, Qiao‐Rong Yi, Shuang Liang, Yue Zhang, Jia‐Chen Liu, Chuan Qiu, Lan‐Juan Zhao, Qing Tian, Kuan‐Jui Su, Zhe Luo, Li Wu, Xiang‐He Meng, Hong‐Mei Xiao, Yun Deng, Yang Li, Dragana Lovre, Vivian Fonseca, Fernando L. Sanchez, Li‐Jun Tan, Hong‐Wen Deng   +21 more
wiley   +1 more source

Efficacy and safety of vitamin D3 B.O.N intramuscular injection in Korean adults with vitamin D deficiency

Osteoporosis and Sarcopenia, 2016
Objective: There has been no prospective study that examined intramuscular injection of high-dose vitamin D in Korean adults. The aim of this study was to assess the efficacy and safety of high-dose vitamin D3 after intramuscular injection in Korean ...
Han Seok Choi, Yoon-Sok Chung, Yong Jun Choi, Da Hea Seo, Sung-Kil Lim   +4 more
doaj   +1 more source

Vitamin D Supplementation and Immune Response to Antarctic Winter [PDF]

, 2011
Maintaining vitamin D status without sunlight exposure is difficult without supplementation. This study was designed to better understand interrelationships between periodic cholecalciferol(vitamin D3) supplementation and immune function in Antarctic ...
Bourbeau, Y., Locke, J. P., Mehta, S. K., Pierson, D. L., Ploutz-Snyder, R., Smith, Scott M., Zwart, S. R.   +6 more
core   +1 more source

Evaluating the impact of maternal vitamin D supplementation: I. Sow performance, serum vitamin metabolites, and neonatal muscle characteristics [PDF]

, 2016
Citation: Flohr, J. R., Woodworth, J. C., Bergstrom, J. R., Tokach, M. D., Dritz, S. S., Goodband, R. D., & DeRouchey, J. M. (2016). Evaluating the impact of maternal vitamin D supplementation: I.
Bergstrom, J. R., DeRouchey, Joel M., Dritz, Steven S., Flohr, Joshua R., Goodband, Robert D., Tokach, Michael D., Woodworth, Jason C.   +6 more
core   +1 more source

Squamate ventricular cardiomyocytes: Ploidy, proliferation, and heart muscle cell size in the leopard gecko (Eublepharis macularius)

Developmental Dynamics, EarlyView.
Abstract Background While heart function is broadly conserved across vertebrates, the cellular phenotype of muscle cells (cardiomyocytes) varies across taxa and throughout ontogeny. Emerging evidence suggests that some attributes may correlate with the capacity for spontaneous cardiomyocyte replacement following injury.
Kathy Jacyniak, Karemna Barrera Jaimes, Minh Hanh Doan, Jordyn M. Chartrand, Matthew K. Vickaryous   +4 more
wiley   +1 more source

Seasonal variation of 25-hydroxyvitamin D3 levels in meat of Moroccan onehumped dromedary camels (Camelus dromedaries) [PDF]

, 2015
In human, vitamin D which derives from the action of sunlight in the skin and dietary intake is of great importance for health, and may be influenced by the season.
Abouhafs, Rachid, Bargaa, Rita, El Abbadi, Najia, El Khasmi, Mohammed, Faye, Bernard, Mohamed, F., Tahri, El Hassan   +6 more
core  

Vitamin D vitamers affect vitamin D status differently in young healthy males [PDF]

, 2017
Dietary intake of vitamin D includes vitamin D3 (vitD3), 25-hydroxyvitamin D3 (25OH-D3), and vitamin D2 (vitD2). However, the bioactivity of the different species has not been scientifically established.
Andersen, Rikke, Bügel, Susanne, Christensen, Tue, Jakobsen, Jette, Wreford Andersen, Elisabeth Anne   +4 more
core   +2 more sources