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Vitamin D3 and calcidiol are not equipotent
The Journal of Steroid Biochemistry and Molecular Biology, 2016Despite the discussion on the optimal threshold of 25-hydroxyvitamin D serum level continues, there is now consensus on the fact that post-menopausal and elderly populations have inadequate Vitamin D serum levels worldwide. The adjustment of these levels is necessary to improve both bone and general health, as it is to optimize bone response to ...
José Manuel Quesada-Gómez +3 more
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Urinary metabolites of vitamin D3
Journal of Steroid Biochemistry, 1980Abstract Relatively little is known regarding the identity of the terminal metabolites of vitamin D 3 , yet measurement of these compounds would give additional useful data on the normal and pathophysioogy of vitamin D in man. We have therefore investigated the metabolism of [26.27- 3 H]-25-hydroxy vitamin D 3 administered orally to a human subject.
C.H.L. Shackleton +2 more
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Questions on the Use of Vitamin D3
Pediatrics, 1980From their observations in a boy with hypophosphatemic rickets Chan and Bartter1 conclude that administration of 1α,25-dihydroxyvitamin D3 (1,25-(OH)2D3) is the treatment of choice for this disease. Since this point of view is not shared by everybody, it demands careful scrutiny.
Robert Steendijk, Sonia Balsan
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Critical Reviews in Eukaryotic Gene Expression, 1998
The physiologically active form of vitamin D3, 1 alpha,25-dihydroxyvitamin D3 (VD), is a nuclear hormone with pleiotropic action on the control of calcium homeostasis and bone formation, induction of cellular differentiation and apoptosis, inhibition of cellular proliferation, and other cellular signaling processes.
Carsten Carlberg, Patsie Polly
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The physiologically active form of vitamin D3, 1 alpha,25-dihydroxyvitamin D3 (VD), is a nuclear hormone with pleiotropic action on the control of calcium homeostasis and bone formation, induction of cellular differentiation and apoptosis, inhibition of cellular proliferation, and other cellular signaling processes.
Carsten Carlberg, Patsie Polly
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Vitamin D3 and Vitamin D3 Analogues as an Adjunct to Cancer Chemotherapy and Radiotherapy
Current Medicinal Chemistry-Anti-Cancer Agents, 2002The development of drugs that are highly selective and yet produce minimal toxicity to host tissue remains one of the most difficult challenges in cancer therapeutics. Since the majority of malignancies are treated with drugs in combination rather than single agents, one practical approach to circumvent this problem is to develop new therapeutic agents
Sujatha Sundaram +2 more
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La Revue de Médecine Interne, 2008
Resume Propos Pres d’un milliard de personnes dans le monde sont carencees en vitamine D et necessiteraient un apport complementaire. La vitamine D est ainsi disponible comme medicament et nutriment. Elle y est presente sous deux formes : vitamine D2 (ergocalciferol) et vitamine D3 (colecalciferol).
Virginie Mistretta +4 more
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Resume Propos Pres d’un milliard de personnes dans le monde sont carencees en vitamine D et necessiteraient un apport complementaire. La vitamine D est ainsi disponible comme medicament et nutriment. Elle y est presente sous deux formes : vitamine D2 (ergocalciferol) et vitamine D3 (colecalciferol).
Virginie Mistretta +4 more
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2016
Most tissue types carry receptors for the vitamin D3 hormone and are therefore receptive to its myriad control signals. It exercises a regulatory function over the activity of at least 200 genes. One important responsibility of this hormone lies in bone metabolism (Chapter 75) and in optimizing the body’s neuromuscular coordination.
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Most tissue types carry receptors for the vitamin D3 hormone and are therefore receptive to its myriad control signals. It exercises a regulatory function over the activity of at least 200 genes. One important responsibility of this hormone lies in bone metabolism (Chapter 75) and in optimizing the body’s neuromuscular coordination.
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Treatment of osteoporosis with vitamin D3
Osteoporosis International, 1993The aims of the treatment of osteoporosis are to halt the rapid decrease in bone mass, and if possible, to increase the bone mass. Appropriate treatment is expected to lower the incidence of bone fracture in patients with a low bone mass by maintaining or increasing bone mass on a long-term basis.
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Archives of Dermatological Research, 1992
The physiologically active metabolite of vitamin D3, 1 alpha,25-dihydroxycolicalciferol [1,25(OH)2D3, calcitriol] has achieved the status of a hormone. It is believed to mediate its effects by binding to a specific receptor which belongs to the family of nuclear receptors for glucocorticoids, estrogens, thyroxine, and retinoid acid.
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The physiologically active metabolite of vitamin D3, 1 alpha,25-dihydroxycolicalciferol [1,25(OH)2D3, calcitriol] has achieved the status of a hormone. It is believed to mediate its effects by binding to a specific receptor which belongs to the family of nuclear receptors for glucocorticoids, estrogens, thyroxine, and retinoid acid.
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Vitamin D3—implications for brain development
The Journal of Steroid Biochemistry and Molecular Biology, 2004There is growing evidence that 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) is active in the brain but until recently there was a lack of evidence about its role during brain development. Guided by certain features of the epidemiology of schizophrenia, our group has explored the role of 1,25(OH)(2)D(3) in brain development using whole animal models and
Thomas H. J. Burne +8 more
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