Results 21 to 30 of about 956,674 (354)

Early‐onset Alzheimer's disease shows a distinct neuropsychological profile and more aggressive trajectories of cognitive decline than late‐onset

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1962-1973, December 2022., 2022
Abstract Objectives Early‐ and late‐onset Alzheimer's disease (EOAD and LOAD) share the same neuropathological traits but show distinct cognitive features. We aimed to explore baseline and longitudinal outcomes of global and domain‐specific cognitive function in a well characterized cohort of patients with a biomarker‐based diagnosis.
Adrià Tort‐Merino, Neus Falgàs, Isabel E. Allen, Mircea Balasa, Jaume Olives, José Contador, Magdalena Castellví, Jordi Juncà‐Parella, Núria Guillén, Sergi Borrego‐Écija, Bea Bosch, Guadalupe Fernández‐Villullas, Oscar Ramos‐Campoy, Anna Antonell, Lorena Rami, Raquel Sánchez‐Valle, Albert Lladó   +16 more
wiley   +1 more source

Vitamin D: sources, physiological role, biokinetics, deficiency, therapeutic use, toxicity, and overview of analytical methods for detection of vitamin D and its metabolites

Critical reviews in clinical laboratory sciences, 2022
Vitamin D has a well-known role in the calcium homeostasis associated with the maintenance of healthy bones. It increases the efficiency of the intestinal absorption of dietary calcium, reduces calcium losses in urine, and mobilizes calcium stored in the
J. Janoušek, Veronika Pilařová, K. Macáková, A. Nomura, Jéssica Veiga-Matos, D. Silva, F. Remião, L. Saso, K. Malá-Ládová, J. Malý, L. Nováková, P. Mladěnka   +11 more
semanticscholar   +1 more source

Estimation of the Number Needed to Treat, the Number Needed to be Exposed, and the Exposure Impact Number with Instrumental Variables [PDF]

Epidemiologic Methods, 13(S2), 2024, Article 20230034, 2023
The Number needed to treat (NNT) is an efficacy index defined as the average number of patients needed to treat to attain one additional treatment benefit. In observational studies, specifically in epidemiology, the adequacy of the populationwise NNT is questionable since the exposed group characteristics may substantially differ from the unexposed. To
arxiv   +1 more source

High prevalence of vitamin D deficiency among the South Asian adults: a systematic review and meta-analysis

BMC Public Health, 2021
Vitamin-D deficiency is linked to a wide range of chronic and infectious diseases. Body of literature suggested that the prevalence of this deficiency can have geographical variation.
M. Siddiqee, B. Bhattacharjee, U. R. Siddiqi, Mohammad MeshbahurRahman   +3 more
semanticscholar   +1 more source

Vitamin D deficiency 2.0: an update on the current status worldwide

European Journal of Clinical Nutrition, 2020
Vitamin D testing and the use of vitamin D supplements have increased substantially in recent years. Currently, the role of vitamin D supplementation, and the optimal vitamin D dose and status, is a subject of debate, because large interventional studies
K. Amrein, Mario Scherkl, Magdalena Hoffmann, Stefan Neuwersch-Sommeregger, M. Köstenberger, Adelina Tmava Berisha, G. Martucci, S. Pilz, O. Malle   +8 more
semanticscholar   +1 more source

Dietary Supplements and Nutraceuticals Under Investigation for COVID-19 Prevention and Treatment [PDF]

, 2021
Coronavirus disease 2019 (COVID-19) has caused global disruption and a significant loss of life. Existing treatments that can be repurposed as prophylactic and therapeutic agents could reduce the pandemic's devastation. Emerging evidence of potential applications in other therapeutic contexts has led to the investigation of dietary supplements and ...
arxiv   +1 more source

Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline.

Journal of Clinical Endocrinology and Metabolism, 2011
OBJECTIVE The objective was to provide guidelines to clinicians for the evaluation, treatment, and prevention of vitamin D deficiency with an emphasis on the care of patients who are at risk for deficiency. PARTICIPANTS The Task Force was composed of a
Michael F. Holick, Neil C. Binkley, H.A. Bischoff-Ferrari, Catherine M. Gordon, David A. Hanley, Robert P. Heaney, M. Murad, Connie M. Weaver   +7 more
semanticscholar   +1 more source

Screening for Vitamin D Deficiency in Adults: US Preventive Services Task Force Recommendation Statement.

Journal of the American Medical Association (JAMA), 2021
Importance Vitamin D is a fat-soluble vitamin that performs an important role in calcium homeostasis and bone metabolism and also affects many other cellular regulatory functions outside the skeletal system. Vitamin D requirements may vary by individual;
A. Krist, K. Davidson, C. Mangione, M. Cabana, A. Caughey, E. Davis, Katrina E. Donahue, Chyke A Doubeni, J. Epling, Martha Y. Kubik, Li Li, G. Ogedegbe, D. Owens, L. Pbert, Michael Silverstein, J. Stevermer, Chien-Wen Tseng, J. Wong   +17 more
semanticscholar   +1 more source

The Metabolic Syndrome among Postmenopausal Women in Gorgan [PDF]

, 2012
In this study, we aimed to assess levels of serum 25-hydroxyvitamin D in relation to metabolic syndrome among postmenopausal women in Gorgan. The study group included 100 postmenopausal women who were referred to the different Health Centers in Gorgan ...
Marjani, A., Moghasemi, S.
core   +3 more sources

Vitamin D deficiency is associated with IL-6 levels and monocyte activation in HIV-infected persons [PDF]

, 2017
Immune activation plays a key role in HIV pathogenesis. Markers of inflammation have been associated with vitamin D deficiency in the general population.
Baker, Jason V, Brooks, John T, Gibson, David, Hammer, John, Hullsiek, Katherine Huppler, Kojic, Erna, Manion, Maura, Patel, Pragna, Rhame, Frank, Sereti, Irini, Study to Understand the Natural History of HIV/AIDS in the Era of Effective Antiretroviral Therapy (the `SUN Study\u27) Investigators,, Wilson, Eleanor M. P.   +11 more
core   +3 more sources